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An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion
Journal article   Open access   Peer reviewed

An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion

K. S. S Mccommis, Wesley T Hodges, Daniel K Bricker, D. R. R Wisidagama, Vincent Compan, M. S. S Remedi, C. S. S Thummel and B. N. N Finck
Molecular metabolism, Vol.5(8), pp.602--614
08/2016
DOI: https://doi.org/10.1016/j.molmet.2016.06.016

Abstract

GTT glucose tolerance test IMM inner mitochondrial membrane IPCs Insulin-producing Cells ITT insulin tolerance test MPC1 and MPC2 Mitochondrial Pyruvate Carrier 1 and 2 Pdx1 pancreatic and duodenal homeobox 1 Pyruvate RESPYR REporter Sensitive to PYRuvate Stimulus-coupled secretion b-Cell GSIS glucose-stimulated insulin secretion Drosophila Drosophila insulin-like peptide 2 DILP2 beta-Cell Insulin Mitochondria Diabetes OCR oxygen consumption rates
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