An LC–MS/MS method to determine vancomycin in plasma (total and unbound), urine and renal replacement therapy effluent

Suzanne Parker; Yarmarly Guerra Valero; Jenny Ordóñez Mejia; Claire Roger; Jeffrey Lipman; Jason Roberts; Steven Wallis

doi:10.4155/bio-2017-0019

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An LC–MS/MS method to determine vancomycin in plasma (total and unbound), urine and renal replacement therapy effluent

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An LC–MS/MS method to determine vancomycin in plasma (total and unbound), urine and renal replacement therapy effluent

Suzanne Parker, Yarmarly Guerra Valero, Jenny Ordóñez Mejia, Claire Roger, Jeffrey Lipman, Jason Roberts et Steven Wallis

Bioanalysis, Vol.9(12), pp.911-924

06/2017

DOI: https://doi.org/10.4155/bio-2017-0019

PMID: 28617036

Résumé

Human health and pathology

Life Sciences

Critical illness and medical interventions, such as renal replacement therapy, can cause changes to vancomycin pharmacokinetics and lead to suboptimal dosing. To comprehensively characterize vancomycin pharmacokinetic a method must measure vancomycin in a range of clinical matrices.

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Détails

Titre: An LC–MS/MS method to determine vancomycin in plasma (total and unbound), urine and renal replacement therapy effluent
Créateurs - sans rôle: Suzanne Parker - Centre for Clinical Research [Brisbane]
Yarmarly Guerra Valero - Centre for Clinical Research [Brisbane]
Jenny Ordóñez Mejia - Centre for Clinical Research [Brisbane]
Claire Roger - Unité de réanimation médicale [CHU de Carémeau, Nîmes]
Jeffrey Lipman - Centre for Clinical Research [Brisbane]
Jason Roberts - Centre for Clinical Research [Brisbane]
Steven Wallis - Centre for Clinical Research [Brisbane]
Détails de publication: Bioanalysis, Vol.9(12), pp.911-924
Éditeur: Future Science
Nombre de pages: 14
Identifiants: 99139980509311
Unité académique: Initial MAnagement & prevent of acute orGan failures IN critically ill patiEnts - IMAGINE
Langue: English
Type de ressource: Journal article