An IDH1-vitamin C crosstalk drives human erythroid development by inhibiting pro-oxidant mitochondrial metabolism

Pedro Gonzalez-Menendez; Manuela Romano; Hongxia Yan; Ruhi Deshmukh; Julien Papoin; Leal Oburoglu; Marie Daumur; Anne-Sophie Dumé; Ira Phadke; Cédric Mongellaz; Xiaoli Qu; Phuong-Nhi Bories; Michaela Fontenay; Xiuli An; Valérie Dardalhon; Marc Sitbon; Valérie Zimmermann; Patrick G Gallagher; Saverio Tardito; Lionel Blanc; Narla Mohandas; Naomi Taylor; Sandrina Kinet

doi:10.1016/j.celrep.2021.108723

Back

An IDH1-vitamin C crosstalk drives human erythroid development by inhibiting pro-oxidant mitochondrial metabolism

Journal article

Open access

Peer reviewed

An IDH1-vitamin C crosstalk drives human erythroid development by inhibiting pro-oxidant mitochondrial metabolism

Pedro Gonzalez-Menendez, Manuela Romano, Hongxia Yan, Ruhi Deshmukh, Julien Papoin, Leal Oburoglu, Marie Daumur, Anne-Sophie Dumé, Ira Phadke, Cédric Mongellaz, …

Cell Reports, Vol.34(5)

02/2021

DOI: https://doi.org/10.1016/j.celrep.2021.108723

Abstract

Highlights d Glutamine-dependent OXPHOS drives early erythroid differentiation d OXPHOS-induced ROS inhibit erythroblast enucleation d IDH1 downregulation augments ROS, leading to pathological erythroid differentiation d Vitamin C rescues erythroid differentiation under conditions of oxidative stress

Files and links (2)

url

Find in HALView

url

https://doi.org/10.1016/j.celrep.2021.108723View

Published (Version of record) Open

Metrics

1 Record Views

Details

Title: An IDH1-vitamin C crosstalk drives human erythroid development by inhibiting pro-oxidant mitochondrial metabolism
Creators - without role: Pedro Gonzalez-Menendez - Institut de Génétique Moléculaire de Montpellier
Manuela Romano - Institut de Génétique Moléculaire de Montpellier
Hongxia Yan - Institut de Génétique Moléculaire de Montpellier
Ruhi Deshmukh - Cancer Research UK Scotland Institute
Julien Papoin - Feinstein Institute for Medical Research
Leal Oburoglu - Laboratory of Excellence GR-Ex
Marie Daumur - Université de Montpellier, Institut de Génétique Moléculaire de Montpellier - IGMM
Anne-Sophie Dumé - Laboratory of Excellence GR-Ex
Ira Phadke - Laboratory of Excellence GR-Ex
Cédric Mongellaz - Université de Montpellier, Institut de Génétique Moléculaire de Montpellier - IGMM
Xiaoli Qu - New York Blood Center
Phuong-Nhi Bories - Institut Cochin
Michaela Fontenay - Institut Cochin
Xiuli An - New York Blood Center
Valérie Dardalhon - Université de Montpellier, Institut de Génétique Moléculaire de Montpellier - IGMM
Marc Sitbon - Université de Montpellier, Institut de Génétique Moléculaire de Montpellier - IGMM
Valérie Zimmermann - Université de Montpellier, Institut de Génétique Moléculaire de Montpellier - IGMM
Patrick G Gallagher - Yale University
Saverio Tardito - Cancer Research UK Scotland Institute
Lionel Blanc - Feinstein Institute for Medical Research
Narla Mohandas - New York Blood Center
Naomi Taylor - Laboratory of Excellence GR-Ex
Sandrina Kinet - Université de Montpellier, Institut de Génétique Moléculaire de Montpellier - IGMM
Publication Details: Cell Reports, Vol.34(5)
Identifiers: 9939109109311
Academic Unit: Institut de Génétique Moléculaire de Montpellier - IGMM
Language: English
Resource Type: Journal article
Local Fields: hal-03161590