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An Early Postnatal Oxytocin Treatment Prevents Social and Learning Deficits in Adult Mice Deficient for Magel2, a Gene Involved in Prader-Willi Syndrome and Autism
Journal article   Peer reviewed

An Early Postnatal Oxytocin Treatment Prevents Social and Learning Deficits in Adult Mice Deficient for Magel2, a Gene Involved in Prader-Willi Syndrome and Autism

Hamid Meziane, Fabienne Schaller, Sylvian Bauer, Claude Villard, Valéry Matarazzo, Fabrice Riet, Gilles Guillon, Daniel Lafitte, Michel G Desarménien, Maïthé Tauber, …
Biological Psychiatry, Vol.78(2), pp.85 - 94
07/2015
DOI: https://doi.org/10.1016/j.biopsych.2014.11.010
PMID: 25599930

Abstract

Autism spectrum disorder MAGEL2 Neurodevelopment Oxytocin Prader-Willi syndrome Therapy
Mutations of MAGEL2 have been reported in patients presenting with autism, and loss of MAGEL2 is also associated with Prader-Willi syndrome, a neurodevelopmental genetic disorder. This study aimed to determine the behavioral phenotype of Magel2-deficient adult mice, to characterize the central oxytocin (OT) system of these mutant mice, and to test the curative effect of a peripheral OT treatment just after birth.
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