Amidation by reactive extrusion for the synthesis of active pharmaceutical ingredients teriflunomide and moclobemide

Matthieu Lavayssiere; Frédéric Lamaty

doi:10.1039/d2cc06934b

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Amidation by reactive extrusion for the synthesis of active pharmaceutical ingredients teriflunomide and moclobemide

Journal article

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Amidation by reactive extrusion for the synthesis of active pharmaceutical ingredients teriflunomide and moclobemide

Matthieu Lavayssiere and Frédéric Lamaty

Chemical Communications, Vol.59(23), pp.3439-3442

2023

DOI: https://doi.org/10.1039/d2cc06934b

Abstract

mechanochemistry

flow chemistry

reactive extrusion

twin screw extruder

solvent-free

API

moclobemide

teriflunomide

The solventless synthesis of an amide was performed in a twinscrew extruder in the presence of a coupling agent, providing a high yielding and productive method. The reaction conditions were optimized to prepare APIs, teriflunomide and moclobemide.

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Title: Amidation by reactive extrusion for the synthesis of active pharmaceutical ingredients teriflunomide and moclobemide
Creators - without role: Matthieu Lavayssiere - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Frédéric Lamaty - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Publication Details: Chemical Communications, Vol.59(23), pp.3439-3442
Identifiers: 9945675709311
Academic Unit: Institut des Biomolécules Max Mousseron - IBMM
Language: English
Resource Type: Journal article
Local Fields: hal-04032659