Résumé
We have compared the stability of α and β anomeric oligonucleotides in NIH 3T3 cellular extracts. We had already shown that α are much more resistant than β oligonucleotides towards purified nucleases. This result is confirmed when using cellular extracts although the difference is smaller. When α molecules are combined with an intercalating agent binding in the 3′ position a synergistic increase of resistance to degradation is observed.