Adherence to treatment in allergic rhinitis using mobile technology. The MASK Study

Luis Midão; Sinthia Bosnic‐anticevich; Rojin Rajabian‐soderlund; Sylvie Arnavielhe; Isabella Annesi‐maesano; Josep Antó; Govert de Vries; Valentina Orlando; Désirée Larenas‐linnemann; Giulia de Feo; Joao Fonseca; Mario Morais‐almeida; Ana Maria Pereira; Ana Maria Todo‐bom; Karl Christian Bergmann; Ralph Mosges; Nikos Papadopoulos; Emmanuel Prokopakis; Regina Roller‐wirnsberger; Peter Valentin Tomazic; Alvaro Cruz; Wytske Fokkens; Jean‐françois Fontaine; Sanna Toppila‐salmi; Peter Hellings; Erik Melen; Carsten Bindslev‐jensen; Robyn O'Hehir; Bilun Gemicioğlu; Ömer Kalayci; Juan Carlos Ivancevich; Jean Bousquet; Pw Hellings; W Aberer; I Agache; Ca Akdis; M Akdis; Mr Aliberti; R Almeida; F Amat; R Angles; I Annesi‑maesano; Ij Ansotegui; Jm Anto ‑; S Arnavielle; E Asayag; A Asarnoj; H Arshad; F Avolio; E Bacci; Claus Bachert; I Baiardini; C Barbara; M Barbagallo; I Baroni; Ba Barreto; X Basagana; Ed Bateman; M Bedolla‑barajas; Anna Bedbrook; Mike Bewick; B Beghé; Eh Bel; Kc Bergmann; Ks Bennoor; M Benson; L Bertorello; Az Białoszewski; T Bieber; Slawomir Bialek; C Bindslev‑jensen; L Bjermer; H Blain; F Blasi; A Blua; M Bochenska Marciniak; I Bogus‑buczynska; Al Boner; M Bonini; S Bonini; Cs Bosnic‑anticevich; Isabelle Bosse; J Bouchard; Lp Boulet; R Bourret; Pj Bousquet; F Braido; Vitalis Briedis; Ce Brightling; J Brozek; C Bucca; R Buhl; R Buonaiuto; C Panaitescu; Mt Burguete Cabañas; E Burte; A Bush; F Caballero‑fonseca; D Caillaud; D Caimmi; Ma Calderon; Pam Camargos; T Camuzat; G Canfora; Gw Canonica; Vicky Cardona; Kh Carlsen; P Carreiro‑martins; Am Carriazo; W Carr; C Cartier; T Casale; G Castellano; Lorenzo Cecchi; Am Cepeda; Nh Chavannes; Y Chen; R Chiron; T Chivato; E Chkhartishvili; Ag Chuchalin; Kf Chung; Mm Ciaravolo; A Ciceran; Cemal Cingi; G Ciprandi; Ac Carvalho Coehlo; L Colas; E Colgan; J Coll; D Conforti; J Correia De Sousa; Rm Cortés‑grimaldo; F Corti; Elísio Costa; Mc Costa‑dominguez; Anne-Lise Courbis; L Cox; M Crescenzo; Aa Cruz; A Custovic; Wienczyslawa Czarlewski; Se Dahlen; G D’amato; C Dario; J Da Silva; Y Dauvilliers; U Darsow; F De Blay; G De Carlo; T Dedeu; M de Fátima Emerson; G De Feo; G De Vries; B De Martino; Np Motta Rubina; D Deleanu; P Demoly; Ja Denburg; Philippe Devillier; S Di Capua Ercolano; N Di Carluccio; A Didier; D Dokic; Mg Dominguez‑silva; H Douagui; Gérard Dray; R Dubakiene; Sr Durham; G Du Toit; Ms Dykewicz; Y El‑gamal; P Eklund; Esben Eller; R Emuzyte; J Farrell; A Farsi; J Ferreira de Mello Jr; J Ferrero; A Fink‑wagner; A Fiocchi; Wj Fokkens; Ja Fonseca; Jf Fontaine; S Forti; Jm Fuentes‑perez; Jl Gálvez‑romero; A Gamkrelidze; J Garcia‑aymerich; Cy García‑cobas; Mh Garcia‑cruz; B Gemicio Ğ Lu; S Genova; G Christoff; Je Gereda; R Gerth Van Wijk; Rm Gomez; J Gómez‑vera; S González Diaz; M Gotua; I Grisle; M Guidacci; Na Guldemond; Z Gutter; Ma Guzmán; Tari Haahtela; J Hajjam; L Hernández; Jo’b Hourihane; Yr Huerta‑villalobos; M Humbert; G Iaccarino; M. Illario; Z Ispayeva; Jc Ivancevich; Ej Jares; E Jassem; Sl Johnston; G Joos; Ks Jung; J Just; M Jutel; I Kaidashev; O Kalayci; Af Kalyoncu; J Karjalainen; P Kardas; Thomas Keil; Pk Keith; M Khaitov; N Khaltaev; J Kleine‑tebbe; Ludger Klimek; Ml Kowalski; M Kuitunen; I Kull; Piotr Kuna; M Kupczyk; Violeta Kvedariene; E Krzych‑fałta; P Lacwik; D Larenas‑linnemann; Daniel Laune; D Lauri; J Lavrut; Ltt Le; M Lessa; G Levato; J Li; P Lieberman; A Lipiec; B Lipworth; Kc Lodrup Carlsen; R Louis; O Lourenço; Ja Luna‑pech; A Magnan; B Mahboub; D Maier; Alpana Mair; I Majer; João Malva; E Mandajieva; P Manning; E de Manuel Keenoy; Gd Marshall; Mr Masjedi; Jf Maspero; Jj Matta Campos; Al Matos; M Maurer; S Mavale‑manuel; O Mayora; Ma Medina‑avalos; E Melén; E Melo‑gomes; Eo Meltzer; Enrica Menditto; J Mercier; N Miculinic; F Mihaltan; B Milenkovic; G Moda; Md Mogica‑martinez; Y Mohammad; I Momas; S Montefort; R Monti; D Mora Bogado; M Morais‑almeida; Ff Morato‑castro; R Mösges; A Mota‑pinto; P Moura Santo; Joaquim Mullol; L Münter; A Muraro; R Murray; R Naclerio; R Nadif; M Nalin; L Napoli; L Namazova‑baranova; H Neffen; V Niedeberger; K Nekam; A Neou; A Nieto; L Nogueira‑silva; M Nogues; Ettore Novellino; Td Nyembue; Re O’hehir; C Odzhakova; K Ohta; Y Okamoto; K Okubo; Gl Onorato; M Ortega Cisneros; S Ouedraogo; I Pali‑schöll; S Palkonen; P Panzner; Ng Papadopoulos; Hs Park; A Papi; G Passalacqua; E Paulino; R Pawankar; S Pedersen; Jl Pépin; Am Pereira; M Persico; Oliver Pfaar; J Phillips; R Picard; B Pigearias; I Pin; C Pitsios; D Plavec; W Pohl; Ta Popov; F Portejoie; P Potter; Ac Pozzi; D Price; Ep Prokopakis; R Puy; B Pugin; Re Pulido Ross; M Przemecka; Kf Rabe; F Raciborski; R Rajabian‑soderlund; Sietze Reitsma; I Ribeirinho; J Rimmer; D Rivero‑yeverino; Ja Rizzo; Mc Rizzo; C Robalo‑cordeiro; F Rodenas; X Rodo; M Rodriguez Gonzalez; L Rodriguez‑mañas; C Rolland; S Rodrigues Valle; M Roman Rodriguez; A Romano; E Rodriguez‑zagal; G Rolla; Re Roller‑wirnsberger; M Romano; J Rosado‑pinto; N. Rosario; M Rottem; Dermot Ryan; H Sagara; J Salimäki; Boleslaw Samolinski; M Sanchez‑borges; J Sastre‑dominguez; Gk Scadding; Hj Schunemann; N Scichilone; P Schmid‑grendelmeier; Fs Serpa; S Shamai; Aziz Sheikh; M Sierra; Fer Simons; V Siroux; Jc Sisul; I Skrindo; D Solé; D Somekh; M Sondermann; T Sooronbaev; M Sova; M Sorensen; M Sorlini; O Spranger; Cristiana Stellato; R Stelmach; R Stukas; J Sunyer –; J Strozek; A Szylling; Jn Tebyriçá; M Thibaudon; T To; A Todo‑bom; Pv Tomazic; S Toppila‑salmi; U Trama; M Triggiani; C Suppli Ulrik; M Urrutia‑pereira; R Valenta; A Valero; Arunas Valiulis; E Valovirta; M Van Eerd; E Van Ganse; M Van Hague; O Vandenplas; Mt Ventura; G Vezzani; T Vasankari; A Vatrella; Mt Verissimo; F Viart; G Viegi; D Vicheva; T Vontetsianos; M Wagenmann; S Walker; D Wallace; Dy Wang; S Waserman; T Werfel; M Westman; Magnus Wickman; Dm Williams; S Williams; N Wilson; J Wright; P Wroczynski; P Yakovliev; Bp Yawn; Pk Yiallouros; A Yorgancioglu; Om Yusuf; Hj Zar; L Zhang; N Zhong; Me Zernotti; I Zhanat; M Zidarn; Torsten Zuberbier; C Zubrinich; A Zurkuhlen

doi:10.1111/cea.13333

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Adherence to treatment in allergic rhinitis using mobile technology. The MASK Study

Journal article

Peer reviewed

Adherence to treatment in allergic rhinitis using mobile technology. The MASK Study

Luis Midão, Sinthia Bosnic‐anticevich, Rojin Rajabian‐soderlund, Sylvie Arnavielhe, Isabella Annesi‐maesano, Josep Antó, Govert de Vries, Valentina Orlando, Désirée Larenas‐linnemann, Giulia de Feo, …

Clinical and Experimental Allergy, Vol.49(4), pp.442-460

04/2019

DOI: https://doi.org/10.1111/cea.13333

Abstract

BackgroundMobile technology may help to better understand the adherence to treatment. MASK‐rhinitis (Mobile Airways Sentinel NetworK for allergic rhinitis) is a patient‐centred ICT system. A mobile phone app (the Allergy Diary) central to MASK is available in 22 countries.ObjectivesTo assess the adherence to treatment in allergic rhinitis patients using the Allergy Diary App.MethodsAn observational cross‐sectional study was carried out on all users who filled in the Allergy Diary from 1 January 2016 to 1 August 2017. Secondary adherence was assessed by using the modified Medication Possession Ratio (MPR) and the Proportion of days covered (PDC) approach.ResultsA total of 12 143 users were registered. A total of 6 949 users reported at least one VAS data recording. Among them, 1 887 users reported ≥7 VAS data. About 1 195 subjects were included in the analysis of adherence. One hundred and thirty‐six (11.28%) users were adherent (MPR ≥70% and PDC ≤1.25), 51 (4.23%) were partly adherent (MPR ≥70% and PDC = 1.50) and 176 (14.60%) were switchers. On the other hand, 832 (69.05%) users were non‐adherent to medications (MPR <70%). Of those, the largest group was non‐adherent to medications and the time interval was increased in 442 (36.68%) users.Conclusion and clinical relevanceAdherence to treatment is low. The relative efficacy of continuous vs on‐demand treatment for allergic rhinitis symptoms is still a matter of debate. This study shows an approach for measuring retrospective adherence based on a mobile app. This also represents a novel approach for analysing medication‐taking behaviour in a real‐world setting.

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Title: Adherence to treatment in allergic rhinitis using mobile technology. The MASK Study
Creators - without role: Luis Midão - Rede de Química e Tecnologia
Sinthia Bosnic‐anticevich - Woolcock Institute of Medical Research
Rojin Rajabian‐soderlund - Karolinska University Hospital
Sylvie Arnavielhe - Kyomed
Isabella Annesi‐maesano - Institut Pierre Louis d‘Épidémiologie et de Santé Publique
Josep Antó - Center for Research in Environmental Epidemiology
Govert de Vries
Valentina Orlando - University of Naples Federico II
Désirée Larenas‐linnemann - Hospital Médica Sur
Giulia de Feo - University of Salerno
Joao Fonseca - Universidade do Porto
Mario Morais‐almeida - CUF Porto Hospital
Ana Maria Pereira
Ana Maria Todo‐bom - Hospitais da Universidade de Coimbra
Karl Christian Bergmann
Ralph Mosges - University of Cologne
Nikos Papadopoulos
Emmanuel Prokopakis - University of Crete
Regina Roller‐wirnsberger - Medical University of Graz
Peter Valentin Tomazic - Medical University of Graz
Alvaro Cruz - Universidade Federal da Bahia
Wytske Fokkens - Academic Medical Center
Jean‐françois Fontaine - Fractionnation of AgroResources and Environment
Sanna Toppila‐salmi - University of Helsinki
Peter Hellings - University of Amsterdam
Erik Melen - Karolinska Institutet
Carsten Bindslev‐jensen - Odense University Hospital
Robyn O'Hehir - Department of Allergy, Immunology and Respiratory Medicine
Bilun Gemicioğlu - Istanbul University
Ömer Kalayci - Hacettepe University
Juan Carlos Ivancevich
Jean Bousquet - Vieillissement et Maladies Chroniques. Approches Epidémiologiques et de santé publique
Pw Hellings
W Aberer
I Agache
Ca Akdis
M Akdis
Mr Aliberti
R Almeida
F Amat
R Angles
I Annesi‑maesano
Ij Ansotegui
Jm Anto ‑
S Arnavielle
E Asayag
A Asarnoj
H Arshad
F Avolio
E Bacci
Claus Bachert - Ghent University Hospital
I Baiardini
C Barbara
M Barbagallo
I Baroni
Ba Barreto
X Basagana
Ed Bateman
M Bedolla‑barajas
Anna Bedbrook - Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon
Mike Bewick
B Beghé
Eh Bel
Kc Bergmann
Ks Bennoor
M Benson
L Bertorello
Az Białoszewski
T Bieber
Slawomir Bialek
C Bindslev‑jensen
L Bjermer
H Blain
F Blasi
A Blua
M Bochenska Marciniak
I Bogus‑buczynska
Al Boner
M Bonini
S Bonini
Cs Bosnic‑anticevich
Isabelle Bosse - Roche
J Bouchard
Lp Boulet
R Bourret
Pj Bousquet
F Braido
Vitalis Briedis - Lithuanian University of Health Sciences
Ce Brightling
J Brozek
C Bucca
R Buhl
R Buonaiuto
C Panaitescu
Mt Burguete Cabañas
E Burte
A Bush
F Caballero‑fonseca
D Caillaud
D Caimmi
Ma Calderon
Pam Camargos
T Camuzat
G Canfora
Gw Canonica
Vicky Cardona
Kh Carlsen
P Carreiro‑martins
Am Carriazo
W Carr
C Cartier
T Casale
G Castellano
Lorenzo Cecchi - Azienda Usl Toscana Centro
Am Cepeda
Nh Chavannes
Y Chen
R Chiron
T Chivato
E Chkhartishvili
Ag Chuchalin
Kf Chung
Mm Ciaravolo
A Ciceran
Cemal Cingi - Eskişehir Osmangazi University
G Ciprandi
Ac Carvalho Coehlo
L Colas
E Colgan
J Coll
D Conforti
J Correia De Sousa
Rm Cortés‑grimaldo
F Corti
Elísio Costa - Universidade do Porto
Mc Costa‑dominguez
Anne-Lise Courbis - Laboratoire de Génie Informatique et d'Ingénierie de Production
L Cox
M Crescenzo
Aa Cruz
A Custovic
Wienczyslawa Czarlewski - UCB Pharma, Colombes
Se Dahlen
G D’amato
C Dario
J Da Silva
Y Dauvilliers
U Darsow
F De Blay
G De Carlo
T Dedeu
M de Fátima Emerson
G De Feo
G De Vries
B De Martino
Np Motta Rubina
D Deleanu
P Demoly
Ja Denburg
Philippe Devillier - Université Paris-Saclay
S Di Capua Ercolano
N Di Carluccio
A Didier
D Dokic
Mg Dominguez‑silva
H Douagui
Gérard Dray - Laboratoire de Génie Informatique et d'Ingénierie de Production
R Dubakiene
Sr Durham
G Du Toit
Ms Dykewicz
Y El‑gamal
P Eklund
Esben Eller - Odense University Hospital
R Emuzyte
J Farrell
A Farsi
J Ferreira de Mello Jr
J Ferrero
A Fink‑wagner
A Fiocchi
Wj Fokkens
Ja Fonseca
Jf Fontaine - Fractionnation of AgroResources and Environment
S Forti
Jm Fuentes‑perez
Jl Gálvez‑romero
A Gamkrelidze
J Garcia‑aymerich
Cy García‑cobas
Mh Garcia‑cruz
B Gemicio Ğ Lu
S Genova
G Christoff
Je Gereda
R Gerth Van Wijk
Rm Gomez
J Gómez‑vera
S González Diaz
M Gotua
I Grisle
M Guidacci
Na Guldemond
Z Gutter
Ma Guzmán
Tari Haahtela - Helsinki University Hospital
J Hajjam
L Hernández
Jo’b Hourihane
Yr Huerta‑villalobos
M Humbert
G Iaccarino
M. Illario - Federico II University Hospital
Z Ispayeva
Jc Ivancevich
Ej Jares
E Jassem
Sl Johnston
G Joos
Ks Jung
J Just
M Jutel
I Kaidashev
O Kalayci
Af Kalyoncu
J Karjalainen
P Kardas
Thomas Keil - Zimmer Biomet
Pk Keith
M Khaitov
N Khaltaev
J Kleine‑tebbe
Ludger Klimek - German Society for Otorhinolaryngology HNS
Ml Kowalski
M Kuitunen
I Kull
Piotr Kuna - Medical University of Lodz
M Kupczyk
Violeta Kvedariene - Vilnius University
E Krzych‑fałta
P Lacwik
D Larenas‑linnemann
Daniel Laune - Université de Montpellier, Institut de Recherche en Infectiologie de Montpellier - IRIM
D Lauri
J Lavrut
Ltt Le
M Lessa
G Levato
J Li
P Lieberman
A Lipiec
B Lipworth
Kc Lodrup Carlsen
R Louis
O Lourenço
Ja Luna‑pech
A Magnan
B Mahboub
D Maier
Alpana Mair - Scottish Government
I Majer
João Malva - University of Coimbra
E Mandajieva
P Manning
E de Manuel Keenoy
Gd Marshall
Mr Masjedi
Jf Maspero
Jj Matta Campos
Al Matos
M Maurer
S Mavale‑manuel
O Mayora
Ma Medina‑avalos
E Melén - Karolinska Institutet
E Melo‑gomes
Eo Meltzer
Enrica Menditto - University of Naples Federico II
J Mercier
N Miculinic
F Mihaltan
B Milenkovic
G Moda
Md Mogica‑martinez
Y Mohammad
I Momas
S Montefort
R Monti
D Mora Bogado
M Morais‑almeida
Ff Morato‑castro
R Mösges - University of Cologne
A Mota‑pinto
P Moura Santo
Joaquim Mullol - Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
L Münter
A Muraro
R Murray
R Naclerio
R Nadif
M Nalin
L Napoli
L Namazova‑baranova
H Neffen
V Niedeberger
K Nekam
A Neou
A Nieto
L Nogueira‑silva
M Nogues
Ettore Novellino - University of Naples Federico II
Td Nyembue
Re O’hehir
C Odzhakova
K Ohta
Y Okamoto
K Okubo
Gl Onorato
M Ortega Cisneros
S Ouedraogo
I Pali‑schöll
S Palkonen
P Panzner
Ng Papadopoulos
Hs Park
A Papi
G Passalacqua
E Paulino
R Pawankar
S Pedersen
Jl Pépin
Am Pereira
M Persico
Oliver Pfaar - Philipps University of Marburg
J Phillips
R Picard
B Pigearias
I Pin
C Pitsios
D Plavec
W Pohl
Ta Popov
F Portejoie
P Potter
Ac Pozzi
D Price
Ep Prokopakis
R Puy
B Pugin
Re Pulido Ross
M Przemecka
Kf Rabe
F Raciborski
R Rajabian‑soderlund
Sietze Reitsma - University of Amsterdam
I Ribeirinho
J Rimmer
D Rivero‑yeverino
Ja Rizzo
Mc Rizzo
C Robalo‑cordeiro
F Rodenas
X Rodo
M Rodriguez Gonzalez
L Rodriguez‑mañas
C Rolland
S Rodrigues Valle
M Roman Rodriguez
A Romano
E Rodriguez‑zagal
G Rolla
Re Roller‑wirnsberger
M Romano
J Rosado‑pinto
N. Rosario
M Rottem
Dermot Ryan - University of Edinburgh
H Sagara
J Salimäki
Boleslaw Samolinski - Medical University of Warsaw
M Sanchez‑borges
J Sastre‑dominguez
Gk Scadding
Hj Schunemann
N Scichilone
P Schmid‑grendelmeier
Fs Serpa
S Shamai
Aziz Sheikh - University of Edinburgh
M Sierra
Fer Simons
V Siroux
Jc Sisul
I Skrindo
D Solé
D Somekh
M Sondermann
T Sooronbaev
M Sova
M Sorensen
M Sorlini
O Spranger
Cristiana Stellato - University of Salerno
R Stelmach
R Stukas
J Sunyer –
J Strozek
A Szylling
Jn Tebyriçá
M Thibaudon
T To
A Todo‑bom
Pv Tomazic
S Toppila‑salmi
U Trama
M Triggiani
C Suppli Ulrik
M Urrutia‑pereira
R Valenta
A Valero
Arunas Valiulis - European Union of Medical Specialists
E Valovirta
M Van Eerd
E Van Ganse
M Van Hague
O Vandenplas
Mt Ventura
G Vezzani
T Vasankari
A Vatrella
Mt Verissimo
F Viart
G Viegi
D Vicheva
T Vontetsianos
M Wagenmann
S Walker
D Wallace
Dy Wang
S Waserman
T Werfel
M Westman
Magnus Wickman - Uppsala University
Dm Williams
S Williams
N Wilson
J Wright
P Wroczynski
P Yakovliev
Bp Yawn
Pk Yiallouros
A Yorgancioglu
Om Yusuf
Hj Zar
L Zhang
N Zhong
Me Zernotti
I Zhanat
M Zidarn
Torsten Zuberbier - Berlin Institute of Health at Charité - Universitätsmedizin Berlin
C Zubrinich
A Zurkuhlen
Publication Details: Clinical and Experimental Allergy, Vol.49(4), pp.442-460
Identifiers: 9938989009311
Academic Unit: Institut de Recherche en Infectiologie de Montpellier - IRIM
Language: English
Resource Type: Journal article
Local Fields: hal-02440649