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Added value of antiphosphatidylserine/prothrombin antibodies in the workup of obstetric antiphospholipid syndrome: communication from the ISTH SSC Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibodies
Journal article   Open access   Peer reviewed

Added value of antiphosphatidylserine/prothrombin antibodies in the workup of obstetric antiphospholipid syndrome: communication from the ISTH SSC Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibodies

Arne Vandevelde, Jean-Christophe Gris, Gary Moore, Jacek Musiał, Stéphane Zuily, Denis Wahl and Katrien M.J. Devreese
Journal of Thrombosis and Haemostasis, Vol.21(7), pp.1981-1994
07/2023
DOI: https://doi.org/10.1016/j.jtha.2023.04.001
PMID: 37061133

Abstract

antiphospholipid antibodies antiphospholipid syndrome obstetric phosphatidylserines pregnancy complications prothrombin thrombosis Female Humans Prothrombin Pregnancy Antibodies, Anticardiolipin Antibodies, Antiphospholipid Antiphospholipid Syndrome Immunoglobulin G Immunoglobulin M Lupus Coagulation Inhibitor Phosphatidylserines
The added value of antiphosphatidylserine/prothrombin antibodies (aPS/PT) in the diagnostic workup of antiphospholipid syndrome (APS) is unclear. Currently, diagnosis of thrombotic APS (TAPS) and obstetric APS (OAPS) requires persistent presence of lupus anticoagulant (LAC), anticardiolipin (aCL) immunoglobulin (Ig) G/IgM, or anti-β2-glycoprotein I (aβ2GPI) IgG/IgM antibodies.
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