Added value of 18F-florbetaben amyloid PET in the diagnostic workup of most complex patients with dementia in France: A naturalistic study

Mathieu Ceccaldi; Thérèse Jonveaux; Antoine Verger; Pierre Krolak-Salmon; Claire Houzard; Olivier Godefroy; Trevor Shields; Audrey Perrotin; Rossella Gismondi; Santiago Bullich; Aleksandar Jovalekic; Nicola Raffa; Florence Pasquier; Franck Semah; Bruno Dubois; Marie-Odile Habert; David Wallon; Mathieu Chastan; Pierre Payoux; Olivier Felician; Mira Didic; Claude Gueriot; Lejla Koric; Radka Kletchkova-Gantchev; Daniela Andriuta; Agnès Devendeville; Diane Dupuis; Ingrid Binot; Mélanie Barbay; Marc-Etienne Meyer; Véronique Moullard; Eloi Magnin; Ludivine Chamard; Sophie Haffen; Clément Drouet; Hatem Boulahdour; Philippe Goas; Solène Querellou-Lefranc; Vincent de La Sayette; Julien Cogez; Pierre Branger; Denis Agostini; Alain Manrique; Yannick Bejot; Agnès Jacquin-Piques; Inna Dygai-Cochet; Alina Berriolo-Riedinger; Olivier Moreaud; Mathilde Sauvee; Céline Gallazzani Crépin; Stéphanie Bombois; Thibaud Lebouvier; Marie-Anne Mackowiak-Cordoliani; Vincent Deramecourt; Adeline Rollin-Sillaire; Pascaline Cassagnaud-Thuillet; Yaohua Chen; Grégory Petyt; Denis Federico; Keren Liora Danaila; Yves Guilhermet; Christophe Magnier; Zaza Makaroff; Isabelle Rouch; Jing Xie; Caroline Roubaud; Marie-Hélène Coste; Kenny David; Alain Sarciron; Aziza Sediq Waissi; Christian Scheiber; Audrey Gabelle-Deloustal; Karim Bennys; Cecilia Marelli; Lynda Touati; Delphine de Verbizier-Lonjon; Athanase Benetos; Anna Kearney-Schwartz; Christine Perret-Guillaume; Martine Vercelletto; Claire Boutoleau-Bretonniere; Hélène Pouclet-Courtemanche; Nathalie Wagemann; Amandine Pallardy; Jacques Hugon; Claire Paquet; Julien Dumurgier; Pascal Millet; Mathieu Queneau; Stéphane Epelbaum; Marcel Levy; Jean-Luc Novella; Yacine Jaidi; David Morland; Serge Belliard; Anne Salmon; Florence Lejeune; Didier Hannequin; Olivier Martinaud; Aline Zarea; Jérémie Pariente; Claire Thalamas; Monique Galitzky-Gerber; Anne-Marie Tricoire Ricard; Fabienne Calvas; Emilie Rigal; Anne Hitzel; Julien Delrieu; Pierre-Jean Ousset; Françoise Lala; Nathalie Sastre-Hengan; Olivier Morel; Olivier Rouaud; Denis Mariano-Goulart; Dimitri Papathanassiou; Florence Le Jeune; Andrew Stephens; Eric Guedj

doi:10.1016/j.jalz.2017.09.009

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Added value of 18F-florbetaben amyloid PET in the diagnostic workup of most complex patients with dementia in France: A naturalistic study

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Added value of 18F-florbetaben amyloid PET in the diagnostic workup of most complex patients with dementia in France: A naturalistic study

Mathieu Ceccaldi, Thérèse Jonveaux, Antoine Verger, Pierre Krolak-Salmon, Claire Houzard, Olivier Godefroy, Trevor Shields, Audrey Perrotin, Rossella Gismondi, Santiago Bullich, …

Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol.14(3), pp.293-305

03/2018

DOI: https://doi.org/10.1016/j.jalz.2017.09.009

PMID: 29107051

Abstract

Florbetaben

Patient management

Diagnosis

Clinical practice

Alzheimer's disease

Amyloid imaging

Aged

Amyloid

Stilbenes

Aniline Compounds

Brain

Dementia

Diagnosis, Differential

Female

France

Humans

Male

Positron-Emission Tomography

Radiopharmaceuticals

IntroductionAlthough some studies have previously addressed the clinical impact of amyloid positron emission tomography (PET), none has specifically addressed its selective and hierarchical implementation in relation to cerebrospinal fluid analysis in a naturalistic setting.MethodsThis multicenter study was performed at French tertiary memory clinics in patients presenting with most complex clinical situations (i.e., early-onset, atypical clinical profiles, suspected mixed etiological conditions, unexpected rate of progression), for whom cerebrospinal fluid analysis was indicated but either not feasible or considered as noncontributory (ClinicalTrials.gov: NCT02681172).ResultsTwo hundred five patients were enrolled with evaluable florbetaben PET scans; 64.4% of scans were amyloid positive. PET results led to changed diagnosis and improved confidence in 66.8% and 81.5% of patients, respectively, and altered management in 80.0% of cases.DiscussionHigh-level improvement of diagnostic certainty and management is provided by selective and hierarchical implementation of florbetaben PET into current standard practices for the most complex dementia cases.

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Title: Added value of 18F-florbetaben amyloid PET in the diagnostic workup of most complex patients with dementia in France: A naturalistic study
Creators - without role: Mathieu Ceccaldi - Institut de Neurosciences des Systèmes
Thérèse Jonveaux - Centre Hospitalier Régional et Universitaire de Nancy
Antoine Verger - Inserm
Pierre Krolak-Salmon - Hospices Civils de Lyon
Claire Houzard - Inserm
Olivier Godefroy - Centre Hospitalier Universitaire Amiens-Picardie
Trevor Shields - Centre Hospitalier Universitaire Amiens-Picardie
Audrey Perrotin - Piramal
Rossella Gismondi - Piramal
Santiago Bullich - Charmo University
Aleksandar Jovalekic - Université Paris Cité
Nicola Raffa - Inserm
Florence Pasquier - Inserm
Franck Semah - Inserm
Bruno Dubois - Hôpital de la Timone
Marie-Odile Habert - Institut de Neurosciences des Systèmes
David Wallon - Inserm
Mathieu Chastan - Hôpital de la Timone
Pierre Payoux - Hôpital de la Timone
Olivier Felician - Institut de Neurosciences des Systèmes
Mira Didic - Hôpital de la Timone
Claude Gueriot - Aix-Marseille Université
Lejla Koric - Hôpital de la Timone
Radka Kletchkova-Gantchev - Hôpital de la Timone
Daniela Andriuta - Hôpital de la Timone
Agnès Devendeville - Inserm
Diane Dupuis - Inserm
Ingrid Binot - Aix-Marseille Université
Mélanie Barbay - Hôpital de la Timone
Marc-Etienne Meyer - Hôpital de la Timone
Véronique Moullard - Aix-Marseille Université
Eloi Magnin - Inserm
Ludivine Chamard - Hôpital de la Timone
Sophie Haffen - Hôpital de la Timone
Clément Drouet - Inserm
Hatem Boulahdour - Inserm
Philippe Goas - Inserm
Solène Querellou-Lefranc
Vincent de La Sayette - Inserm
Julien Cogez - Hôpital de la Timone
Pierre Branger - Inserm
Denis Agostini - Inserm
Alain Manrique - Inserm
Yannick Bejot - Inserm
Agnès Jacquin-Piques - Hôpital de la Timone
Inna Dygai-Cochet - Inserm
Alina Berriolo-Riedinger - Inserm
Olivier Moreaud - Aix-Marseille Université
Mathilde Sauvee - Inserm
Céline Gallazzani Crépin - Inserm
Stéphanie Bombois - Inserm
Thibaud Lebouvier - Inserm
Marie-Anne Mackowiak-Cordoliani
Vincent Deramecourt - Inserm
Adeline Rollin-Sillaire - Aix-Marseille Université
Pascaline Cassagnaud-Thuillet - Hôpital de la Timone
Yaohua Chen - Hôpital de la Timone
Grégory Petyt - Inserm
Denis Federico - Inserm
Keren Liora Danaila - Inserm
Yves Guilhermet - Inserm
Christophe Magnier - Aix-Marseille Université
Zaza Makaroff - Inserm
Isabelle Rouch - Inserm
Jing Xie - Inserm
Caroline Roubaud - Hôpital de la Timone
Marie-Hélène Coste
Kenny David - Inserm
Alain Sarciron - Hôpital de la Timone
Aziza Sediq Waissi - Inserm
Christian Scheiber - Inserm
Audrey Gabelle-Deloustal - Aix-Marseille Université
Karim Bennys - Inserm
Cecilia Marelli - Institut de Neurosciences des Systèmes
Lynda Touati - Hôpital de la Timone
Delphine de Verbizier-Lonjon - Hôpital de la Timone
Athanase Benetos - Inserm
Anna Kearney-Schwartz - Inserm
Christine Perret-Guillaume - Institut de Neurosciences des Systèmes
Martine Vercelletto - Inserm
Claire Boutoleau-Bretonniere - Hôpital de la Timone
Hélène Pouclet-Courtemanche - Inserm
Nathalie Wagemann - Inserm
Amandine Pallardy - Hôpital de la Timone
Jacques Hugon - Inserm
Claire Paquet - Hôpital de la Timone
Julien Dumurgier - Hôpital de la Timone
Pascal Millet - Inserm
Mathieu Queneau - Inserm
Stéphane Epelbaum - Inserm
Marcel Levy - Inserm
Jean-Luc Novella
Yacine Jaidi - Inserm
David Morland - Piramal
Serge Belliard - Hôpital de la Timone
Anne Salmon - Inserm
Florence Lejeune - Hôpital de la Timone
Didier Hannequin - Inserm
Olivier Martinaud - Inserm
Aline Zarea - Hôpital de la Timone
Jérémie Pariente - Centre Henri Becquerel
Claire Thalamas - Inserm
Monique Galitzky-Gerber - Université de Lille
Anne-Marie Tricoire Ricard
Fabienne Calvas - Inserm
Emilie Rigal - Université Toulouse III - Paul Sabatier
Anne Hitzel - Inserm
Julien Delrieu - Université de Rouen Normandie
Pierre-Jean Ousset
Françoise Lala - Inserm
Nathalie Sastre-Hengan - Inserm
Olivier Morel - Hôpital de la Timone
Olivier Rouaud - Aix-Marseille Université
Denis Mariano-Goulart - Université de Montpellier, Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp
Dimitri Papathanassiou - Inserm
Florence Le Jeune - Comportement et noyaux gris centraux = Behavior and Basal Ganglia [Rennes]
Andrew Stephens - Aix-Marseille Université
Eric Guedj - Hôpital de la Timone
Publication Details: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol.14(3), pp.293-305
Grant note: H. Lundbeck A/S
Identifiers: 9941216609311
Academic Unit: Institut des Neurosciences de Montpellier - INM; Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp
Language: English
Resource Type: Journal article
Local Fields: hal-03266901