Acute liver failure following immune checkpoint inhibitors

Thomas Renault; Lucy Meunier; Clément Monet

doi:10.1016/j.clinre.2023.102203

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Acute liver failure following immune checkpoint inhibitors

Journal article

Open access

Peer reviewed

Acute liver failure following immune checkpoint inhibitors

Thomas Renault, Lucy Meunier and Clément Monet

Clinics and Research in Hepatology and Gastroenterology, Vol.47(8)

10/2023

DOI: https://doi.org/10.1016/j.clinre.2023.102203

Abstract

Acute liver failure

Immune check point inhibitors

Immunotherapy

Drug-induced

Liver injury

Plasma exchange

We report the case of a 64-year-old man admitted to intensive care unit for liver failure secondary to immune-mediated hepatitis. This patient suffered from a progressing laryngeal squamous cell carcinoma. A treatment was started with immune checkpoint inhibitors combining anti PD-L1 plus novel anti-TIGIT or placebo (ATEZOLIZUMAB plus TIRAGOLUMAB or placebo), as part of a clinical trial. The patient then developed immune-mediated hepatitis, proven by liver biopsy. Despite 14 days of corticosteroids at 2 mg/kg the condition of the patient worsened, with the development of liver failure. The patient was admitted to intensive care unit, treated with plasma exchange, and made a complete recovery from this life-threatening condition. To our knowledge this is the case of a successful use of plasma exchange to treat ATEZOLIZUMAB +/- TIRAGOLUMAB induced liver toxicity.

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Title: Acute liver failure following immune checkpoint inhibitors
Creators - without role: Thomas Renault - Université de Montpellier
Lucy Meunier - Université de Montpellier, Cell souches plasticité cellul régénérat tissulaire immuno des maladies inflamm - IRMB
Clément Monet - Université de Montpellier, Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp
Publication Details: Clinics and Research in Hepatology and Gastroenterology, Vol.47(8)
Identifiers: 9938230609311
Academic Unit: Cell souches plasticité cellul régénérat tissulaire immuno des maladies inflamm - IRMB; Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp
Language: English
Resource Type: Journal article
Local Fields: hal-04205722