Accelerated surgery versus standard care in hip fracture (HIP ATTACK): an international, randomised, controlled trial

Flavia K. Borges; Mohit Bhandari; Ernesto Guerra-Farfan; Ameen Patel; Alben Sigamani; Masood Umer; Maria E. Tiboni; Maria del Mar Villar-Casares; Vikas Tandon; Jordi Tomas-Hernandez; Jordi Teixidor-Serra; Victoria R. A. Avram; Mitchell Winemaker; Mmampapatla T. Ramokgopa; Wojciech Szczeklik; Giovanni Landoni; Chew Yin Wang; Dilshad Begum; John D. Neary; Anthony Adili; Parag K. Sancheti; Abdel-Rahman Lawendy; Mariano Balaguer-Castro; Pawel Sleczka; Richard J. Jenkinson; Aamer Nabi Nur; Gavin C. A. Wood; Robert J. Feibel; Stephen J. McMahon; Alen Sigamani; Ekaterine Popova; Bruce M. Biccard; Iain K. Moppett; Patrice Forget; Paul Landais; Michael H. McGillion; Jessica Vincent; Kumar Balasubramanian; Valerie Harvey; Yaiza Garcia-Sanchez; Shirley M. Pettit; Leslie P. Gauthier; Gordon H. Guyatt; David Conen; Amit X. Garg; Shrikant I. Bangdiwala; Emilie P. Belley-Cote; Maura Marcucci; Andre Lamy; Richard Whitlock; Yannick Le Manach; Dean A. Fergusson; Salim Yusuf; P. J. Devereaux; Laurent Veevaete; Bernard le Polain de Waroux; Patricia Lavand'homme; Olivier Cornu; Karim Tribak; Jean Cyr Yombi; Nassim Touil; Maike Reul; Jigme Tshering Bhutia; Carol Clinckaert; Dirk De Clippeleir; Justin de Beer; Diane L. Simpson; Andrew Worster; Kim A. Alvarado; Krysten K. Gregus; Kelly H. Lawrence; Darryl P. Leong; Philip G. Joseph; Patrick Magloire; Benjamin Deheshi; Stuart Bisland; Thomas J. Wood; Daniel M. Tushinski; David A. J. Wilson; Clive Kearon; David D. Cowan; Vickas Khanna; Amna Zaki; Janet C. Farrell; Anne Marie MacDonald; Steven C. W. Wong; Arsha Karbassi; Douglas Steven Wright; Harsha Shanthanna; Ryan Coughlin; Moin Khan; Spencer Wikkerink; Faraaz A. Quraishi; Waleed Kishta; Emil Schemitsch; Timothy Carey; Mark D. Macleod; David W. Sanders; Edward Vasarhelyi; Debra Bartley; George K. Dresser; Christina Tieszer; Steven Shadowitz; Jacques S. Lee; Stephen Choi; Hans J. Kreder; Markku Nousiainen; Monica R. Kunz; Ravianne Tuazon; Mopina Shrikumar; Bheeshma Ravi; David Wasserstein; David J. G. Stephen; Diane Nam; Patrick D. G. Henry; Stephen M. Mann; Melanie T. Jaeger; Marco L. A. Sivilotti; Christopher A. Smith; Christopher C. Frank; Heather Grant; Leone Ploeg; Jeff D. Yach; Mark M. Harrison; Aaron R. Campbell; Ryan T. Bicknell; Davide D. Bardana; Katie McIlquham; Catherine Gallant; Samantha Halman; Venkatesh Thiruganasambandamoorth; Sara Ruggiero; William J. Hadden; Brian P-J Chen; Stephanie A. Coupal; Lisa M. McLean; Hemant R. Shirali; Syed Y. Haider; Crystal A. Smith; Evan Watts; David J. Santone; Kevin Koo; Allan J. Yee; Ademilola N. Oyenubi; Aaron Nauth; Emil H. Schemitsch; Timothy R. Daniels; Sarah E. Ward; Jeremy A. Hall; Henry Ahn; Daniel B. Whelan; Amit Atrey; Amir Khoshbin; David Puskas; Kurt Droll; Claude Cullinan; Jubin Payendeh; Tina Lefrancois; Lise Mozzon; Travis Marion; Michael J. Jacka; James Greene; Matthew Menon; Robert Stiegelmahr; Derek Dillane; Marleen Irwin; Lauren Beaupre; Chad P. Coles; Kelly Trask; Shelley MacDonald; J. Andrew I. Trenholm; William Oxner; C. Glen Richardson; Niloofar Dehghan; Mehdi Sadoughi; Achal Sharma; Neil J. White; Loretta Olivieri; Stephen B. Hunt; Thomas R. Turgeon; Eric R. Bohm; Sarah Tran; Stephen M. Giilck; Tom Hupel; Pierre Guy; Peter J. O'Brien; Andrew W. Duncan; Gordon A. Crawford; Junlin Zhou; Yanrui Zhao; Yang Liu; Lei Shan; Anshi Wu; Juan Manuel Munoz; Philippe Chaudier; Marion Douplat; Michel Henri Fessy; Vincent Piriou; Lucie Louboutin; Jean Stephane David; Arnaud Friggeri; Sebastien Beroud; Jean Marie Fayet; Frankie Ka Li Leung; Christian Xinshuo Fang; Dennis King Hang Yee; Parag Kantilal Sancheti; Chetan Vijay Pradhan; Atul Ashok Patil; Chetan Prabhakar Puram; Madhav Pandurang Borate; Kiran Bhalchandra Kudrimoti; Bharati Anil Adhye; Himanshu Vijaykumar Dongre; Bobby John; Valsamma Abraham; Ritesh Arvind Pandey; Arti Rajkumar; Preetha Elizabeth George; Manesh Stephen; Nitheesh Chandran; Mohammed Ashraf; A. M. Georgekutty; Ahamad Shaheel Sulthan; S. Adinarayanan; Deep Sharma; Satish Prasad Barnawal; Srinivasan Swaminathan; Prasanna Udupi Bidkar; Sandeep Kumar Mishra; Jagdish Menon; M. Niranjan; Varghese K. Zachariah; Santosh Angad Hiremath; N. C. Madhusudhan; Abhijit Jawali; Kingsly Robert Gnanadurai; Carolin Elizabeth George; Tatarao Maddipati; K. P. Mary; Vijay Sharma; Kamran Farooque; Rajesh Malhotra; Samarth Mittal; Chavi Sawhney; Babita Gupta; Purva Mathur; Shivanand Gamangati; Vijaylaxmi Tripathy; Prem Haridas Menon; Mandeep S. Dhillon; Devendra K. Chouhan; Sharanu Patil; Ravi Narayan; Purushotham Lal; Prashanth Nabhirajappa Bilchod; Surya Udai Singh; Uttam Vaidya Gattu; Ravi Prabhakar Dashputra; Prashant Vitthal Rahate; Maurizio Turiel; Giuseppe De Blasio; Riccardo Accetta; Paolo Perazzo; Daniele Stella; Marika Bonadies; Chiara Colombo; Stefania Fozzato; Fabio Pino; Ilaria Morelli; Eleonora Colnaghi; Vincenzo Salini; Giuseppe Denaro; Luigi Beretta; Giacomo Placella; Giuseppe Giardina; Mirko Binda; Anna Marcato; Luca Guzzetti; Fabio Piccirillo; Maurizio Cecconi; H. M. Khor; Hou Yee Lai; C. S. Kumar; K. H. Chee; P. S. Loh; Kit Mun Tan; Simmrat Singh; Li Lian Foo; Komella Prakasam; Sook Hui Chaw; Meng-Li Lee; Joanne H. L. Ngim; Huck Wee Boon; Im Im Chin; Ydo V. Kleinlugtenbelt; Ellie B. M. Landman; Elvira R. Flikweert; Herbert W. Roerdink; Roy B. G. Brokelman; Hannie F. Elskamp-Meijerman; Maarten R. Horst; Jan-Hein M. G. Cobben; Anila Anjum; Pervaiz Mehmood Hashmi; Tashfeen Ahmed; Haroon Ur Rashid; Mujahid Jamil Khattak; Rizwan Haroon Rashid; Riaz Hussain Lakdawala; Shahryar Noordin; Naveed Muhammed Juman; Robyna Irshad Khan; Muhammad Mehmood Riaz; Syedah Saira Bokhari; Ayesha Almas; Hussain Wahab; Arif Ali; Hammad Naqi Khan; Eraj Khurshid Khan; Kholood Abid Janjua; Sajjad Hassan Orakzai; Abdus Salam Khan; Khawaja Junaid Mustafa; Mian Amjad Sohail; Muhammad Umar; Siddra Ahmed Khan; Muhammad Ashraf; Muhammad Kashif Khan; Muhammad Shiraz; Ahmad Furgan; Piotr Dabek; Adam Kumon; Wojciech Satora; Wojciech Ambrozy; Mariusz Swiech; Jacek Rycombel; Adrian Grzelak; Jaroslaw Gucwa; Waldemar Machala; Mmampapatla Thomas Ramokgopa; Gregory Bodley Firth; Mwalimu Karera; Maria Fourtounas; Virsen Singh; Anna Biscardi; Muhammad Nasir Iqbal; Ryan Jonathan Campbell; Matimba Lenny Maluleke; Carien Moller; Lerato Nhlapo; Sithombo Maqungo; Margot Flint; Marcin B. Nejthardt; Sean Chetty; Rubendren Naidoo; Miriam Garrido Clua; Vicente Molero-Garcia; Joan Minguell-Monyart; Jordi Selga Marsa; Juan A. Porcel-Vazquez; Jose-Vicente Andres-Peiro; Marc Aguilar; Jaume Mestre-Torres; Maria J. Colomina; Patricia Guilabert; M. Luisa Panos Gozalo; Luis Abarca; Nuria Martin; Gemma Usua; Pedro Martinez-Ripol; M. A. Gonzalez Posada; Pilar Lalueza-Broto; Judith Sanchez-Raya; Jorge Nunez Camarena; Antoni Fraguas-Castany; Pere Torner; Monsant Jornet-Gibert; Jorge Serrano-Sanz; Jaume Camara-Cabrera; Monica Salomo-Domenech; Christian Yela-Verdu; Anna Peig-Font; Laura Ricol; Anna Carreras-Castaner; Luis Martinez-Sanudo; Susana Herranz; Carlos Feijoo-Masso; Monica Sianes-Gallen; Pablo Castillon; Marti Bernaus; Saioa Quintas; Olga Gomez; Jordi Salvador; Javiera Abarca; Cristina Estrada; Marga Novellas; Merce Torra; Alfred Dealbert; Oscar Macho; Alexia Ivanov; Esther Valldosera; Marta Arroyo; Borja Pey; Antoni Yuste; Llorenc Mateo; Julio De Caso; Rafael Anaya; J. L. Higa-Sansone; Angelica Millan; Victoria Banos; Sergio Herrera-Mateo; Hector J. Aguado; Gonzalo Martinez-Municio; Ricardo Leon; Silvia Santiago-Maniega; Ana Zabalza; Gregorio Labrador; Enrique Guerado; Encarnacion Cruz; Juan Ramon Cano; Jose Manuel Bogallo; Paphon Sa-Ngasoongsong; Noratep Kulachote; Norachart Sirisreetreerux; Nachapan Pengrung; Theerawat Chalacheewa; Vanlapa Arnuntasupakul; Teerapat Yingchoncharoen; Bundit Naratreekoon; Miriam Adel Kadry; Surendini Thayaparan; Ihab Abdlaziz; Arash Aframian; Arjuna Imbuldeniya; Souad Bentoumi; Sherif Omran; Marcela Paola Vizcaychipi; Patricia Correia; Shashank Patil; Kevin Haire; Amy S. E. Mayor; Sally Dillingham; Laura Nicholson; Mohamed Elnaggar; Joby John; Shashi Kumar Nanjayan; Martyn J. Parker; Susan O'Sullivan; Meir T. Marmor; Amir Matityahu; Robert Trigg McClellan; Curt Comstock; Anthony Ding; Paul Toogood; Gerard Slobogean; Katherine Joseph; Robert O'Toole; Marcus Sciadini; Scott P. Ryan; Molly E. Clark; Charles Cassidy; Konstantin Balonov; Sergio D. Bergese; Laura S. Phieffer; Alicia A. Gonzalez Zacarias; Andrew J. Marcantonio; Sanela Dragic-Taylor; Chelsea Maxwell; Sarah Molnar; Jennifer R. Wells; Sandra N. Ofori; Stephen S. Yang; Michael K. Wang; Emmanuelle Duceppe; Jessica Spence; Javiera P. Vasquez; Francesc Marcano-Fernandez; Hyungjoo Ham; Carlos Prada; Terence C. H. Yung; Isidro Sanz Perez; Michael J. Bosch; Michael R. Prystajecky; Chinmoy Chowdhury; James S. Khan; Steffan F. Stella; Behrouz Heidary; Allen Tran; Katarzyna Wawrzycka-Adamczyk; Yu Chiao Peter Chen; Aranzazu Gonzalez-Osuna; Grzegorz Biedron; Anna Wludarczyk; Marco Lefebvre; Jaclyn A. Ernst; Bas Staffhorst; Jason D. Woodfine; Emad M. Alwafi; Marko Mrkobrada; Simon Parlow; Robin Roberts; Finlay McAlister; David Sackett; James Wright; HIP ATTACK Investigators

doi:10.1016/S0140-6736(20)30058-1

Retour

$Accelerated surgery versus standard care in hip fracture (HIP ATTACK): an international, randomised, controlled trial$

Article de revue

Avec comité de lecture

Accelerated surgery versus standard care in hip fracture (HIP ATTACK): an international, randomised, controlled trial

Flavia K. Borges, Mohit Bhandari, Ernesto Guerra-Farfan, Ameen Patel, Alben Sigamani, Masood Umer, Maria E. Tiboni, Maria del Mar Villar-Casares, Vikas Tandon, Jordi Tomas-Hernandez, …

The Lancet (British edition), Vol.395(10225), pp.698-708

29/02/2020

DOI: https://doi.org/10.1016/S0140-6736(20)30058-1

PMID: 32050090

Résumé

General & Internal Medicine

Life Sciences & Biomedicine

Medicine, General & Internal

Science & Technology

Background Observational studies have suggested that accelerated surgery is associated with improved outcomes in patients with a hip fracture. The HIP ATTACK trial assessed whether accelerated surgery could reduce mortality and major complications. Methods HIP ATTACK was an international, randomised, controlled trial done at 69 hospitals in 17 countries. Patients with a hip fracture that required surgery and were aged 45 years or older were eligible. Research personnel randomly assigned patients (1:1) through a central computerised randomisation system using randomly varying block sizes to either accelerated surgery (goal of surgery within 6 h of diagnosis) or standard care. The coprimary outcomes were mortality and a composite of major complications (ie, mortality and non-fatal myocardial infarction, stroke, venous thromboembolism, sepsis, pneumonia, life-threatening bleeding, and major bleeding) at 90 days after randomisation. Patients, health-care providers, and study staff were aware of treatment assignment, but outcome adjudicators were masked to treatment allocation. Patients were analysed according to the intention-to-treat principle. This study is registered at ClinicalTrials.gov (NCT02027896). Findings Between March 14, 2014, and May 24, 2019, 27 701 patients were screened, of whom 7780 were eligible. 2970 of these were enrolled and randomly assigned to receive accelerated surgery (n=1487) or standard care (n=1483). The median time from hip fracture diagnosis to surgery was 6 h (IQR 4-9) in the accelerated-surgery group and 24 h (10-42) in the standard-care group (p<0.0001). 140 (9%) patients assigned to accelerated surgery and 154 (10%) assigned to standard care died, with a hazard ratio (HR) of 0.91 (95% CI 0.72 to 1.14) and absolute risk reduction (ARR) of 1% (-1 to 3; 1:0.40). Major complications occurred in 321 (22%) patients assigned to accelerated surgery and 331 (22%) assigned to standard care, with an HR of 0.97 (0.83 to 1.13) and an ARR of 1% (-2 to 4; p=0.71). Interpretation Among patients with a hip fracture, accelerated surgery did not significantly lower the risk of mortality or a composite of major complications compared with standard care. Copyright (C) 2020 Elsevier Ltd. All rights reserved.

Indicateurs

1 Consultations de la notice

See more details

Détails

Titre: Accelerated surgery versus standard care in hip fracture (HIP ATTACK): an international, randomised, controlled trial
Créateurs - sans rôle: Flavia K. Borges - McMaster Univ, Dept Med, Hamilton, ON, Canada
Mohit Bhandari - McMaster Univ, Dept Surg, Hamilton, ON, Canada
Ernesto Guerra-Farfan - Vall Hebron Univ Hosp, Dept Orthoped Surg & Traumatol, Barcelona, Spain
Ameen Patel - McMaster Univ, Dept Med, Hamilton, ON, Canada
Alben Sigamani - Narayana Hlth, Dept Clin Res, Bangalore, Karnataka, India
Masood Umer - Aga Khan Univ, Dept Surg, Karachi, Pakistan
Maria E. Tiboni - McMaster Univ, Dept Med, Hamilton, ON, Canada
Maria del Mar Villar-Casares - Vall Hebron Univ Hosp, Dept Internal Med, Barcelona, Spain
Vikas Tandon - McMaster Univ, Dept Med, Hamilton, ON, Canada
Jordi Tomas-Hernandez - Vall Hebron Univ Hosp, Dept Orthoped Surg & Traumatol, Barcelona, Spain
Jordi Teixidor-Serra - Vall Hebron Univ Hosp, Dept Orthoped Surg & Traumatol, Barcelona, Spain
Victoria R. A. Avram - McMaster Univ, Dept Surg, Hamilton, ON, Canada
Mitchell Winemaker - McMaster Univ, Dept Surg, Hamilton, ON, Canada
Mmampapatla T. Ramokgopa - Chris Hani Baragwanath Acad Hosp, Dept Orthopaed Surg, Johannesburg, South Africa
Wojciech Szczeklik - Jagiellonian Univ, Dept Intens Care & Perioperat Med, Coll Med, Krakow, Poland
Giovanni Landoni - IRCCS San Raffaele Sci Inst, Dept Anaesthesia & Intens Care, Milan, Italy
Chew Yin Wang - Univ Malaya, Dept Anaesthesiol, Kuala Lumpur, Malaysia
Dilshad Begum - Aga Khan Univ, Karachi, Pakistan
John D. Neary - McMaster Univ, Dept Med, Hamilton, ON, Canada
Anthony Adili - McMaster Univ, Dept Surg, Hamilton, ON, Canada
Parag K. Sancheti - Sancheti Inst Orthopaed & Rehabil, Dept Orthopaed, Pune, Maharashtra, India
Abdel-Rahman Lawendy - Western Univ, Dept Surg, London Hlth Sci Ctr, London, ON, Canada
Mariano Balaguer-Castro - Parc Tauli Hosp Univ, Dept Orthopaed Surg & Traumatol, Sabadell, Spain
Pawel Sleczka - Samodzielny Publ Zaklad Opieki Zdrowotnej, Dept Orthopaed Surg, Myslenice, Poland
Richard J. Jenkinson - Univ Toronto, Dept Surg, Toronto, ON, Canada
Aamer Nabi Nur - Shifa Int Hosp, Dept Orthopaed, Islamabad, Pakistan
Gavin C. A. Wood - Queens Univ, Div Orthopaed, Kingston, ON, Canada
Robert J. Feibel - Ottawa Hosp, Div Orthopaed Surg, Ottawa, ON, Canada
Stephen J. McMahon - Markham Stouffville Hosp, Dept Surg, Markham, ON, Canada
Alen Sigamani - Govt TD Med Coll Hosp, Alappuzha, Kerala, India
Ekaterine Popova - Biomed Res Inst IIB St Pau, Barcelona, Spain
Bruce M. Biccard - Groote Schuur Hosp, Dept Anaesthesia & Perioperat Med, Cape Town, South Africa
Iain K. Moppett - Univ Nottingham, Queens Med Ctr, Anaesthesia & Crit Care, Div Clin Neurosci, Nottingham, England
Patrice Forget - Univ Aberdeen, Sch Med Med Sci & Nutr, Inst Appl Hlth Sci, Epidemiol Grp,Dept Anaesthesia,NHS Grampian, Aberdeen, Scotland
Paul Landais - Montpellier Univ, Dept Biostat & Clin Res, Montpellier, France
Michael H. McGillion - Populat Hlth Res Inst, Hamilton, ON, Canada
Jessica Vincent - Populat Hlth Res Inst, Hamilton, ON, Canada
Kumar Balasubramanian - Populat Hlth Res Inst, Hamilton, ON, Canada
Valerie Harvey - Populat Hlth Res Inst, Hamilton, ON, Canada
Yaiza Garcia-Sanchez - Vall Hebron Univ Hosp, Dept Orthoped Surg & Traumatol, Barcelona, Spain
Shirley M. Pettit - Populat Hlth Res Inst, Hamilton, ON, Canada
Leslie P. Gauthier - Juravinski Hosp, Hamilton Hlth Sci, Hamilton, ON, Canada
Gordon H. Guyatt - McMaster Univ, Dept Med, Hamilton, ON, Canada
David Conen - McMaster Univ, Dept Med, Hamilton, ON, Canada
Amit X. Garg - McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada
Shrikant I. Bangdiwala - Populat Hlth Res Inst, Hamilton, ON, Canada
Emilie P. Belley-Cote - McMaster Univ, Dept Med, Hamilton, ON, Canada
Maura Marcucci - McMaster Univ, Dept Med, Hamilton, ON, Canada
Andre Lamy - Populat Hlth Res Inst, Hamilton, ON, Canada
Richard Whitlock - Populat Hlth Res Inst, Hamilton, ON, Canada
Yannick Le Manach - Populat Hlth Res Inst, Hamilton, ON, Canada
Dean A. Fergusson - University of Ottawa
Salim Yusuf - McMaster University
P. J. Devereaux - McMaster University
Laurent Veevaete
Bernard le Polain de Waroux
Patricia Lavand'homme
Olivier Cornu
Karim Tribak
Jean Cyr Yombi
Nassim Touil
Maike Reul
Jigme Tshering Bhutia
Carol Clinckaert
Dirk De Clippeleir
Justin de Beer
Diane L. Simpson
Andrew Worster
Kim A. Alvarado
Krysten K. Gregus
Kelly H. Lawrence
Darryl P. Leong
Philip G. Joseph
Patrick Magloire
Benjamin Deheshi
Stuart Bisland
Thomas J. Wood
Daniel M. Tushinski
David A. J. Wilson
Clive Kearon
David D. Cowan
Vickas Khanna
Amna Zaki
Janet C. Farrell
Anne Marie MacDonald
Steven C. W. Wong
Arsha Karbassi
Douglas Steven Wright
Harsha Shanthanna
Ryan Coughlin
Moin Khan
Spencer Wikkerink
Faraaz A. Quraishi
Waleed Kishta
Emil Schemitsch
Timothy Carey
Mark D. Macleod
David W. Sanders
Edward Vasarhelyi
Debra Bartley
George K. Dresser
Christina Tieszer
Steven Shadowitz
Jacques S. Lee
Stephen Choi
Hans J. Kreder
Markku Nousiainen
Monica R. Kunz
Ravianne Tuazon
Mopina Shrikumar
Bheeshma Ravi
David Wasserstein
David J. G. Stephen
Diane Nam
Patrick D. G. Henry
Stephen M. Mann
Melanie T. Jaeger
Marco L. A. Sivilotti
Christopher A. Smith
Christopher C. Frank
Heather Grant
Leone Ploeg
Jeff D. Yach
Mark M. Harrison
Aaron R. Campbell
Ryan T. Bicknell
Davide D. Bardana
Katie McIlquham
Catherine Gallant
Samantha Halman
Venkatesh Thiruganasambandamoorth
Sara Ruggiero
William J. Hadden
Brian P-J Chen
Stephanie A. Coupal
Lisa M. McLean
Hemant R. Shirali
Syed Y. Haider
Crystal A. Smith
Evan Watts
David J. Santone
Kevin Koo
Allan J. Yee
Ademilola N. Oyenubi
Aaron Nauth
Emil H. Schemitsch
Timothy R. Daniels
Sarah E. Ward
Jeremy A. Hall
Henry Ahn
Daniel B. Whelan
Amit Atrey
Amir Khoshbin
David Puskas
Kurt Droll
Claude Cullinan
Jubin Payendeh
Tina Lefrancois
Lise Mozzon
Travis Marion
Michael J. Jacka
James Greene
Matthew Menon
Robert Stiegelmahr
Derek Dillane
Marleen Irwin
Lauren Beaupre
Chad P. Coles
Kelly Trask
Shelley MacDonald
J. Andrew I. Trenholm
William Oxner
C. Glen Richardson
Niloofar Dehghan
Mehdi Sadoughi
Achal Sharma
Neil J. White
Loretta Olivieri
Stephen B. Hunt
Thomas R. Turgeon
Eric R. Bohm
Sarah Tran
Stephen M. Giilck
Tom Hupel
Pierre Guy
Peter J. O'Brien
Andrew W. Duncan
Gordon A. Crawford
Junlin Zhou
Yanrui Zhao
Yang Liu
Lei Shan
Anshi Wu
Juan Manuel Munoz
Philippe Chaudier
Marion Douplat
Michel Henri Fessy
Vincent Piriou
Lucie Louboutin
Jean Stephane David
Arnaud Friggeri
Sebastien Beroud
Jean Marie Fayet
Frankie Ka Li Leung
Christian Xinshuo Fang
Dennis King Hang Yee
Parag Kantilal Sancheti
Chetan Vijay Pradhan
Atul Ashok Patil
Chetan Prabhakar Puram
Madhav Pandurang Borate
Kiran Bhalchandra Kudrimoti
Bharati Anil Adhye
Himanshu Vijaykumar Dongre
Bobby John
Valsamma Abraham
Ritesh Arvind Pandey
Arti Rajkumar
Preetha Elizabeth George
Manesh Stephen
Nitheesh Chandran
Mohammed Ashraf
A. M. Georgekutty
Ahamad Shaheel Sulthan
S. Adinarayanan
Deep Sharma
Satish Prasad Barnawal
Srinivasan Swaminathan
Prasanna Udupi Bidkar
Sandeep Kumar Mishra
Jagdish Menon
M. Niranjan
Varghese K. Zachariah
Santosh Angad Hiremath
N. C. Madhusudhan
Abhijit Jawali
Kingsly Robert Gnanadurai
Carolin Elizabeth George
Tatarao Maddipati
K. P. Mary
Vijay Sharma
Kamran Farooque
Rajesh Malhotra
Samarth Mittal
Chavi Sawhney
Babita Gupta
Purva Mathur
Shivanand Gamangati
Vijaylaxmi Tripathy
Prem Haridas Menon
Mandeep S. Dhillon
Devendra K. Chouhan
Sharanu Patil
Ravi Narayan
Purushotham Lal
Prashanth Nabhirajappa Bilchod
Surya Udai Singh
Uttam Vaidya Gattu
Ravi Prabhakar Dashputra
Prashant Vitthal Rahate
Maurizio Turiel
Giuseppe De Blasio
Riccardo Accetta
Paolo Perazzo
Daniele Stella
Marika Bonadies
Chiara Colombo
Stefania Fozzato
Fabio Pino
Ilaria Morelli
Eleonora Colnaghi
Vincenzo Salini
Giuseppe Denaro
Luigi Beretta
Giacomo Placella
Giuseppe Giardina
Mirko Binda
Anna Marcato
Luca Guzzetti
Fabio Piccirillo
Maurizio Cecconi
H. M. Khor
Hou Yee Lai
C. S. Kumar
K. H. Chee
P. S. Loh
Kit Mun Tan
Simmrat Singh
Li Lian Foo
Komella Prakasam
Sook Hui Chaw
Meng-Li Lee
Joanne H. L. Ngim
Huck Wee Boon
Im Im Chin
Ydo V. Kleinlugtenbelt
Ellie B. M. Landman
Elvira R. Flikweert
Herbert W. Roerdink
Roy B. G. Brokelman
Hannie F. Elskamp-Meijerman
Maarten R. Horst
Jan-Hein M. G. Cobben
Anila Anjum
Pervaiz Mehmood Hashmi
Tashfeen Ahmed
Haroon Ur Rashid
Mujahid Jamil Khattak
Rizwan Haroon Rashid
Riaz Hussain Lakdawala
Shahryar Noordin
Naveed Muhammed Juman
Robyna Irshad Khan
Muhammad Mehmood Riaz
Syedah Saira Bokhari
Ayesha Almas
Hussain Wahab
Arif Ali
Hammad Naqi Khan
Eraj Khurshid Khan
Kholood Abid Janjua
Sajjad Hassan Orakzai
Abdus Salam Khan
Khawaja Junaid Mustafa
Mian Amjad Sohail
Muhammad Umar
Siddra Ahmed Khan
Muhammad Ashraf
Muhammad Kashif Khan
Muhammad Shiraz
Ahmad Furgan
Piotr Dabek
Adam Kumon
Wojciech Satora
Wojciech Ambrozy
Mariusz Swiech
Jacek Rycombel
Adrian Grzelak
Jaroslaw Gucwa
Waldemar Machala
Mmampapatla Thomas Ramokgopa
Gregory Bodley Firth
Mwalimu Karera
Maria Fourtounas
Virsen Singh
Anna Biscardi
Muhammad Nasir Iqbal
Ryan Jonathan Campbell
Matimba Lenny Maluleke
Carien Moller
Lerato Nhlapo
Sithombo Maqungo
Margot Flint
Marcin B. Nejthardt
Sean Chetty
Rubendren Naidoo
Miriam Garrido Clua
Vicente Molero-Garcia
Joan Minguell-Monyart
Jordi Selga Marsa
Juan A. Porcel-Vazquez
Jose-Vicente Andres-Peiro
Marc Aguilar
Jaume Mestre-Torres
Maria J. Colomina
Patricia Guilabert
M. Luisa Panos Gozalo
Luis Abarca
Nuria Martin
Gemma Usua
Pedro Martinez-Ripol
M. A. Gonzalez Posada
Pilar Lalueza-Broto
Judith Sanchez-Raya
Jorge Nunez Camarena
Antoni Fraguas-Castany
Pere Torner
Monsant Jornet-Gibert
Jorge Serrano-Sanz
Jaume Camara-Cabrera
Monica Salomo-Domenech
Christian Yela-Verdu
Anna Peig-Font
Laura Ricol
Anna Carreras-Castaner
Luis Martinez-Sanudo
Susana Herranz
Carlos Feijoo-Masso
Monica Sianes-Gallen
Pablo Castillon
Marti Bernaus
Saioa Quintas
Olga Gomez
Jordi Salvador
Javiera Abarca
Cristina Estrada
Marga Novellas
Merce Torra
Alfred Dealbert
Oscar Macho
Alexia Ivanov
Esther Valldosera
Marta Arroyo
Borja Pey
Antoni Yuste
Llorenc Mateo
Julio De Caso
Rafael Anaya
J. L. Higa-Sansone
Angelica Millan
Victoria Banos
Sergio Herrera-Mateo
Hector J. Aguado
Gonzalo Martinez-Municio
Ricardo Leon
Silvia Santiago-Maniega
Ana Zabalza
Gregorio Labrador
Enrique Guerado
Encarnacion Cruz
Juan Ramon Cano
Jose Manuel Bogallo
Paphon Sa-Ngasoongsong
Noratep Kulachote
Norachart Sirisreetreerux
Nachapan Pengrung
Theerawat Chalacheewa
Vanlapa Arnuntasupakul
Teerapat Yingchoncharoen
Bundit Naratreekoon
Miriam Adel Kadry
Surendini Thayaparan
Ihab Abdlaziz
Arash Aframian
Arjuna Imbuldeniya
Souad Bentoumi
Sherif Omran
Marcela Paola Vizcaychipi
Patricia Correia
Shashank Patil
Kevin Haire
Amy S. E. Mayor
Sally Dillingham
Laura Nicholson
Mohamed Elnaggar
Joby John
Shashi Kumar Nanjayan
Martyn J. Parker
Susan O'Sullivan
Meir T. Marmor
Amir Matityahu
Robert Trigg McClellan
Curt Comstock
Anthony Ding
Paul Toogood
Gerard Slobogean
Katherine Joseph
Robert O'Toole
Marcus Sciadini
Scott P. Ryan
Molly E. Clark
Charles Cassidy
Konstantin Balonov
Sergio D. Bergese
Laura S. Phieffer
Alicia A. Gonzalez Zacarias
Andrew J. Marcantonio
Sanela Dragic-Taylor
Chelsea Maxwell
Sarah Molnar
Jennifer R. Wells
Sandra N. Ofori
Stephen S. Yang
Michael K. Wang
Emmanuelle Duceppe
Jessica Spence
Javiera P. Vasquez
Francesc Marcano-Fernandez
Hyungjoo Ham
Carlos Prada
Terence C. H. Yung
Isidro Sanz Perez
Michael J. Bosch
Michael R. Prystajecky
Chinmoy Chowdhury
James S. Khan
Steffan F. Stella
Behrouz Heidary
Allen Tran
Katarzyna Wawrzycka-Adamczyk
Yu Chiao Peter Chen
Aranzazu Gonzalez-Osuna
Grzegorz Biedron
Anna Wludarczyk
Marco Lefebvre
Jaclyn A. Ernst
Bas Staffhorst
Jason D. Woodfine
Emad M. Alwafi
Marko Mrkobrada
Simon Parlow
Robin Roberts
Finlay McAlister
David Sackett
James Wright
HIP ATTACK Investigators
Détails de publication: The Lancet (British edition), Vol.395(10225), pp.698-708
Éditeur: Elsevier
Nombre de pages: 11
Note de subvention: Ontario Strategy for Patient Oriented Research Support Unit Ontario Ministry of Health and Long-Term Care; Ontario Ministere de la Sante et des Soins de longue duree (MSSLD) Michael G. DeGroote Institute for Pain Research and Care Physicians' Services Incorporated Foundation Smith Nephew Indiegogo Crowdfunding Hamilton Health Sciences Foundation Canadian Institutes of Health Research; Canadian Institutes of Health Research (CIHR)
Identifiants: 99153895109311
Unité académique: Initial MAnagement & prevent of acute orGan failures IN critically ill patiEnts - IMAGINE
Langue: English
Type de ressource: Journal article