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Abstract 2338: CD39 Treg cooperate with a CD73-expressing Th1Th17 subset for Adenosine-mediated immunosuppression in human breast tumors
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Abstract 2338: CD39 Treg cooperate with a CD73-expressing Th1Th17 subset for Adenosine-mediated immunosuppression in human breast tumors

Nicolas Gourdin, Cline Rodriguez, Selena Vigano, Isabelle Durand, Julien Faget, Camilla Jandus, Jean Blay, Pedro Romero, Christine Menetrier-Caux et Christophe Caux
Cancer research (Chicago, Ill.), Vol.76(14_Supplement), pp.2338-2338
15/07/2016

Résumé

Our group and others have previously reported that Treg infiltrating (Ti-Treg) breast tumors have a negative impact on patients outcome. We further reported their selective recruitment in the tumor environment through CCL22 secretion and expansion upon ICOS engagement by plasmacytod dendritic cells.

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