Absence of Δ-9-Tetrahydrocannabinol Dysphoric Effects in Dynorphin-Deficient Mice

Andreas Zimmer; Emmanuel Valjent; Monika König; Anne M. Zimmer; Patricia Robledo; Heidi Hahn; Olga Valverde; Rafael Maldonado

doi:10.1523/JNEUROSCI.21-23-09499.2001

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Absence of Δ-9-Tetrahydrocannabinol Dysphoric Effects in Dynorphin-Deficient Mice

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Absence of Δ-9-Tetrahydrocannabinol Dysphoric Effects in Dynorphin-Deficient Mice

Andreas Zimmer, Emmanuel Valjent, Monika König, Anne M. Zimmer, Patricia Robledo, Heidi Hahn, Olga Valverde et Rafael Maldonado

The Journal of neuroscience, Vol.21(23), pp.9499-9505

01/12/2001

DOI: https://doi.org/10.1523/JNEUROSCI.21-23-09499.2001

PMID: 11717384

Résumé

ARTICLE

The involvement of dynorphin on Δ-9-tetrahydrocannabinol (THC) and morphine responses has been investigated by using mice with a targeted inactivation of the prodynorphin (Pdyn) gene. Dynorphin-deficient mice show specific changes in the behavioral effects of THC, including a reduction of spinal THC analgesia and the absence of THC-induced conditioned place aversion. In contrast, acute and chronic opioid effects were normal. The lack of negative motivational effects of THC in the absence of dynorphin demonstrates that this endogenous opioid peptide mediates the dysphoric effects of marijuana.

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Titre: Absence of Δ-9-Tetrahydrocannabinol Dysphoric Effects in Dynorphin-Deficient Mice
Créateurs - sans rôle: Andreas Zimmer - Laboratory of Genetics, National Institute of Mental Health, Bethesda, Maryland 20892, Psychiatric Clinic, University of Bonn, 53105 Bonn, Germany, and Laboratori de Neurofarmacologia, Facultat de Ciències de la Salut i de la Vida, Universitat Pompeu Fabra, 08003 Barcelona, Spain
Emmanuel Valjent - Laboratory of Genetics, National Institute of Mental Health, Bethesda, Maryland 20892, Psychiatric Clinic, University of Bonn, 53105 Bonn, Germany, and Laboratori de Neurofarmacologia, Facultat de Ciències de la Salut i de la Vida, Universitat Pompeu Fabra, 08003 Barcelona, Spain
Monika König - Laboratory of Genetics, National Institute of Mental Health, Bethesda, Maryland 20892, Psychiatric Clinic, University of Bonn, 53105 Bonn, Germany, and Laboratori de Neurofarmacologia, Facultat de Ciències de la Salut i de la Vida, Universitat Pompeu Fabra, 08003 Barcelona, Spain
Anne M. Zimmer - Laboratory of Genetics, National Institute of Mental Health, Bethesda, Maryland 20892, Psychiatric Clinic, University of Bonn, 53105 Bonn, Germany, and Laboratori de Neurofarmacologia, Facultat de Ciències de la Salut i de la Vida, Universitat Pompeu Fabra, 08003 Barcelona, Spain
Patricia Robledo - Laboratory of Genetics, National Institute of Mental Health, Bethesda, Maryland 20892, Psychiatric Clinic, University of Bonn, 53105 Bonn, Germany, and Laboratori de Neurofarmacologia, Facultat de Ciències de la Salut i de la Vida, Universitat Pompeu Fabra, 08003 Barcelona, Spain
Heidi Hahn - Laboratory of Genetics, National Institute of Mental Health, Bethesda, Maryland 20892, Psychiatric Clinic, University of Bonn, 53105 Bonn, Germany, and Laboratori de Neurofarmacologia, Facultat de Ciències de la Salut i de la Vida, Universitat Pompeu Fabra, 08003 Barcelona, Spain
Olga Valverde - Laboratory of Genetics, National Institute of Mental Health, Bethesda, Maryland 20892, Psychiatric Clinic, University of Bonn, 53105 Bonn, Germany, and Laboratori de Neurofarmacologia, Facultat de Ciències de la Salut i de la Vida, Universitat Pompeu Fabra, 08003 Barcelona, Spain
Rafael Maldonado - Laboratory of Genetics, National Institute of Mental Health, Bethesda, Maryland 20892, Psychiatric Clinic, University of Bonn, 53105 Bonn, Germany, and Laboratori de Neurofarmacologia, Facultat de Ciències de la Salut i de la Vida, Universitat Pompeu Fabra, 08003 Barcelona, Spain
Détails de publication: The Journal of neuroscience, Vol.21(23), pp.9499-9505
Éditeur: Society for Neuroscience
Nombre de pages: 7
Identifiants: 99140197809311
Unité académique: Institut des Neurosciences de Montpellier - INM
Langue: English
Type de ressource: Journal article