Abstract
The HIV-1 auxiliary protein Nef is required for the onset and progression of AIDS in HIV-1-infected persons. Here, we have deciphered the mode of action of a second-generation inhibitor of Nef, DLC27-14, presenting a competitive IC50 of
- Title
- A specific protein disorder catalyzer of HIV-1 Nef
- Creators - without role
- Adrien Lugari - Aix-Marseille UniversitéSebastian Breuer - Scripps Research InstituteThibault Coursindel - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMMSandrine Opi - Institut de Neurobiologie de la MéditerranéeAudrey Restouin - Centre de Recherche en Cancérologie de MarseilleXiaoli Shi - Institut de Microbiologie de la MéditerranéeAlexis Nazabal - Cova IX AGBruce E. Torbett - Scripps Research InstituteJean Martinez - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMMYves Colettte - Institut Paoli-CalmettesIsabelle Parrot - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMMStefan T Arold - The University of Texas MD Anderson Cancer CenterXavier Morelli - Institut de Microbiologie de la Méditerranée
- Publication Details
- Bioorganic and Medicinal Chemistry, Vol.19, pp.7401-7406
- Identifiers
- 9943537409311
- Academic Unit
- Institut des Biomolécules Max Mousseron - IBMM
- Language
- English
- Resource Type
- Journal article
- Local Fields
- hal-00662295