A short phosphodiester window is sufficient to direct RNase H-dependent RNA cleavage by antisense peptide nucleic acid

Journal article

Peer reviewed

C. Malchere, J. Verheijen, S. van Der Laan, L. Bastide, J. Van Boom, B. Lebleu and I. Robbins

Antisense and Nucleic Acid Drug Development, Vol.10(6), pp.463--8

2000

Abstract

Messenger/drug effects/*metabolism Rabbits Ribonuclease H/drug effects/genetics/*metabolism

Drug Escherichia coli/enzymology Gene Targeting Oligonucleotides/*pharmacology Oligonucleotides

Antisense/chemistry/*pharmacology Peptide Nucleic Acids/chemistry/*pharmacology Polymers/pharmacology Protein Biosynthesis/drug effects RNA

Animals Catalysis Cell-Free System DNA/chemistry Dose-Response Relationship

url

Find in HALView

1 Record Views

Title: A short phosphodiester window is sufficient to direct RNase H-dependent RNA cleavage by antisense peptide nucleic acid
Creators - without role: C. Malchere
J. Verheijen
S. van Der Laan
L. Bastide - Centre de Recherches sur les Macromolécules Végétales
J. Van Boom - Max
B. Lebleu - Université de Montpellier, Institut de Génétique Moléculaire de Montpellier - IGMM
I. Robbins - Université de Montpellier, Institut de Génétique Moléculaire de Montpellier - IGMM
Publication Details: Antisense and Nucleic Acid Drug Development, Vol.10(6), pp.463--8
Identifiers: 9946003109311
Academic Unit: Institut de Génétique Moléculaire de Montpellier - IGMM
Language: English
Resource Type: Journal article
Local Fields: hal-02196820