A reference map of the human binary protein interactome

Katja Luck; Dae-Kyum Kim; Luke Lambourne; Kerstin Spirohn; Bridget E Begg; Wenting Bian; Ruth Brignall; Tiziana Cafarelli; Francisco J Campos-Laborie; Benoit Charloteaux; Dongsic Choi; Atina G Coté; Meaghan Daley; Steven Deimling; Alice Desbuleux; Amélie Dricot; Marinella Gebbia; Madeleine F Hardy; Nishka Kishore; Jennifer J Knapp; István A Kovács; Irma Lemmens; Miles W Mee; Joseph C Mellor; Carl Pollis; Carles Pons; Aaron D Richardson; Sadie Schlabach; Bridget Teeking; Anupama Yadav; Mariana Babor; Dawit Balcha; Omer Basha; Christian Bowman-Colin; Suet-Feung Chin; Soon Gang Choi; Claudia Colabella; Georges Coppin; Cassandra D'Amata; David De Ridder; Steffi De Rouck; Miquel Duran-Frigola; Hanane Ennajdaoui; Florian Goebels; Liana Goehring; Anjali Gopal; Ghazal Haddad; Elodie Hatchi; Mohamed Helmy; Yves Jacob; Yoseph Kassa; Serena Landini; Roujia Li; Natascha van Lieshout; Andrew MacWilliams; Dylan Markey; Joseph N Paulson; Sudharshan Rangarajan; John Rasla; Ashyad Rayhan; Thomas Rolland; Adriana San-Miguel; Yun Shen; Dayag Sheykhkarimli; Gloria M Sheynkman; Eyal Simonovsky; Murat Taşan; Alexander Tejeda; Vincent Tropepe; Jean-Claude Twizere; Yang Wang; Robert J Weatheritt; Jochen Weile; Yu Xia; Xinping Yang; Esti Yeger-Lotem; Quan Zhong; Patrick Aloy; Gary D Bader; Javier De Las Rivas; Suzanne Gaudet; Tong Hao; Janusz Rak; Jan Tavernier; David E Hill; Marc Vidal; Frederick P Roth; Michael A Calderwood

doi:10.1038/s41586-020-2188-x

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A reference map of the human binary protein interactome

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A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J Campos-Laborie, Benoit Charloteaux, …

Nature (London), Vol.580(7803), pp.402-408

01/04/2020

DOI: https://doi.org/10.1038/s41586-020-2188-x

PMID: 32296183

Résumé

Extracellular Space - metabolism

Humans

Organ Specificity

Protein Interaction Mapping

Proteome - metabolism

Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships . Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration of HuRI with genome , transcriptome and proteome data enables cellular function to be studied within most physiological or pathological cellular contexts. We demonstrate the utility of HuRI in identifying the specific subcellular roles of protein-protein interactions. Inferred tissue-specific networks reveal general principles for the formation of cellular context-specific functions and elucidate potential molecular mechanisms that might underlie tissue-specific phenotypes of Mendelian diseases. HuRI is a systematic proteome-wide reference that links genomic variation to phenotypic outcomes.

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Titre: A reference map of the human binary protein interactome
Créateurs - sans rôle: Katja Luck - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
Dae-Kyum Kim - Lunenfeld-Tanenbaum Research Institute (LTRI), Sinai Health System, Toronto, Ontario, Canada
Luke Lambourne - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
Kerstin Spirohn - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
Bridget E Begg - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
Wenting Bian - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
Ruth Brignall - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
Tiziana Cafarelli - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
Francisco J Campos-Laborie - Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain
Benoit Charloteaux - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
Dongsic Choi - The Research Institute of the McGill University Health Centre (RI-MUHC), Montreal, Quebec, Canada
Atina G Coté - Lunenfeld-Tanenbaum Research Institute (LTRI), Sinai Health System, Toronto, Ontario, Canada
Meaghan Daley - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
Steven Deimling - Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
Alice Desbuleux - Molecular Biology of Diseases, Groupe Interdisciplinaire de Génomique Appliquée (GIGA) and Laboratory of Viral Interactomes, University of Liège, Liège, Belgium
Amélie Dricot - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
Marinella Gebbia - Lunenfeld-Tanenbaum Research Institute (LTRI), Sinai Health System, Toronto, Ontario, Canada
Madeleine F Hardy - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
Nishka Kishore - Lunenfeld-Tanenbaum Research Institute (LTRI), Sinai Health System, Toronto, Ontario, Canada
Jennifer J Knapp - Lunenfeld-Tanenbaum Research Institute (LTRI), Sinai Health System, Toronto, Ontario, Canada
István A Kovács - Wigner Research Centre for Physics, Institute for Solid State Physics and Optics, Budapest, Hungary
Irma Lemmens - Cytokine Receptor Laboratory (CRL), Department of Biomolecular Medicine, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
Miles W Mee - Department of Computer Science, University of Toronto, Toronto, Ontario, Canada
Joseph C Mellor - seqWell, Beverly, MA, USA
Carl Pollis - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
Carles Pons - Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute for Science and Technology, Barcelona, Catalonia, Spain
Aaron D Richardson - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
Sadie Schlabach - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
Bridget Teeking - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
Anupama Yadav - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
Mariana Babor - Lunenfeld-Tanenbaum Research Institute (LTRI), Sinai Health System, Toronto, Ontario, Canada
Dawit Balcha - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
Omer Basha - National Institute for Biotechnology in the Negev (NIBN), Ben-Gurion University of the Negev, Beer-Sheva, Israel
Christian Bowman-Colin - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
Suet-Feung Chin - Cancer Research UK (CRUK) Cambridge Institute, University of Cambridge, Cambridge, UK
Soon Gang Choi - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
Claudia Colabella - Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche "Togo Rosati" (IZSUM), Perugia, Italy
Georges Coppin - Molecular Biology of Diseases, Groupe Interdisciplinaire de Génomique Appliquée (GIGA) and Laboratory of Viral Interactomes, University of Liège, Liège, Belgium
Cassandra D'Amata - Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
David De Ridder - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
Steffi De Rouck - Cytokine Receptor Laboratory (CRL), Department of Biomolecular Medicine, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
Miquel Duran-Frigola - Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute for Science and Technology, Barcelona, Catalonia, Spain
Hanane Ennajdaoui - Lunenfeld-Tanenbaum Research Institute (LTRI), Sinai Health System, Toronto, Ontario, Canada
Florian Goebels - Department of Computer Science, University of Toronto, Toronto, Ontario, Canada
Liana Goehring - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
Anjali Gopal - Lunenfeld-Tanenbaum Research Institute (LTRI), Sinai Health System, Toronto, Ontario, Canada
Ghazal Haddad - Lunenfeld-Tanenbaum Research Institute (LTRI), Sinai Health System, Toronto, Ontario, Canada
Elodie Hatchi - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
Mohamed Helmy - Department of Computer Science, University of Toronto, Toronto, Ontario, Canada
Yves Jacob - Université Paris Diderot, Paris, France
Yoseph Kassa - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
Serena Landini - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
Roujia Li - Lunenfeld-Tanenbaum Research Institute (LTRI), Sinai Health System, Toronto, Ontario, Canada
Natascha van Lieshout - Lunenfeld-Tanenbaum Research Institute (LTRI), Sinai Health System, Toronto, Ontario, Canada
Andrew MacWilliams - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
Dylan Markey - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
Joseph N Paulson - Department of Biostatistics, Product Development, Genentech Inc., South San Francisco, CA, USA
Sudharshan Rangarajan - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
John Rasla - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
Ashyad Rayhan - Lunenfeld-Tanenbaum Research Institute (LTRI), Sinai Health System, Toronto, Ontario, Canada
Thomas Rolland - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
Adriana San-Miguel - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
Yun Shen - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
Dayag Sheykhkarimli - Lunenfeld-Tanenbaum Research Institute (LTRI), Sinai Health System, Toronto, Ontario, Canada
Gloria M Sheynkman - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
Eyal Simonovsky - National Institute for Biotechnology in the Negev (NIBN), Ben-Gurion University of the Negev, Beer-Sheva, Israel
Murat Taşan - Department of Computer Science, University of Toronto, Toronto, Ontario, Canada
Alexander Tejeda - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
Vincent Tropepe - Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
Jean-Claude Twizere - Molecular Biology of Diseases, Groupe Interdisciplinaire de Génomique Appliquée (GIGA) and Laboratory of Viral Interactomes, University of Liège, Liège, Belgium
Yang Wang - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
Robert J Weatheritt - The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada
Jochen Weile - Department of Computer Science, University of Toronto, Toronto, Ontario, Canada
Yu Xia - Department of Bioengineering, McGill University, Montreal, Quebec, Canada
Xinping Yang - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
Esti Yeger-Lotem - National Institute for Biotechnology in the Negev (NIBN), Ben-Gurion University of the Negev, Beer-Sheva, Israel
Quan Zhong - Department of Biological Sciences, Wright State University, Dayton, OH, USA
Patrick Aloy - Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain
Gary D Bader - Department of Computer Science, University of Toronto, Toronto, Ontario, Canada
Javier De Las Rivas - Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain
Suzanne Gaudet - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
Tong Hao - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
Janusz Rak - The Research Institute of the McGill University Health Centre (RI-MUHC), Montreal, Quebec, Canada
Jan Tavernier - Cytokine Receptor Laboratory (CRL), Department of Biomolecular Medicine, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
David E Hill - Dana-Farber Cancer Institute
Marc Vidal - Harvard Medical School
Frederick P Roth - Canadian Institute for Advanced Research (CIFAR), Toronto, Ontario, Canada. fritz.roth@utoronto.ca
Michael A Calderwood - Dana-Farber Cancer Institute
Détails de publication: Nature (London), Vol.580(7803), pp.402-408
Note de subvention: U01 HL098166 / NHLBI NIH HHS R01 GM109199 / NIGMS NIH HHS U01 HG007690 / NHGRI NIH HHS P50 HG004233 / NHGRI NIH HHS T32 CA009361 / NCI NIH HHS U41 HG001715 / NHGRI NIH HHS
Identifiants: 99149515409311
Unité académique: Centre de Recherche en Biologie Cellulaire de Montpellier - CRBM
Langue: English
Type de ressource: Journal article