A proteome-scale map of the human interactome network

Thomas Rolland; Murat Taşan; Benoit Charloteaux; Samuel J Pevzner; Quan Zhong; Nidhi Sahni; Song Yi; Irma Lemmens; Celia Fontanillo; Roberto Mosca; Atanas Kamburov; Susan D Ghiassian; Xinping Yang; Lila Ghamsari; Dawit Balcha; Bridget E Begg; Pascal Braun; Marc Brehme; Martin P Broly; Anne-Ruxandra Carvunis; Dan Convery-Zupan; Roser Corominas; Jasmin Coulombe-Huntington; Elizabeth Dann; Matija Dreze; Amélie Dricot; Changyu Fan; Eric Franzosa; Fana Gebreab; Bryan J Gutierrez; Madeleine F Hardy; Mike Jin; Shuli Kang; Ruth Kiros; Guan Ning Lin; Katja Luck; Andrew MacWilliams; Jörg Menche; Ryan R Murray; Alexandre Palagi; Matthew M Poulin; Xavier Rambout; John Rasla; Patrick Reichert; Viviana Romero; Elien Ruyssinck; Julie M Sahalie; Annemarie Scholz; Akash A Shah; Amitabh Sharma; Yun Shen; Kerstin Spirohn; Stanley Tam; Alexander O Tejeda; Shelly A Wanamaker; Jean-Claude Twizere; Kerwin Vega; Jennifer Walsh; Michael E Cusick; Yu Xia; Albert-László Barabási; Lilia M Iakoucheva; Patrick Aloy; Javier De Las Rivas; Jan Tavernier; Michael A Calderwood; David E Hill; Tong Hao; Frederick P Roth; Marc Vidal

doi:10.1016/j.cell.2014.10.050

Retour

A proteome-scale map of the human interactome network

Article de revue

Avec comité de lecture

A proteome-scale map of the human interactome network

Thomas Rolland, Murat Taşan, Benoit Charloteaux, Samuel J Pevzner, Quan Zhong, Nidhi Sahni, Song Yi, Irma Lemmens, Celia Fontanillo, Roberto Mosca, …

Cell, Vol.159(5), pp.1212-1226

20/11/2014

DOI: https://doi.org/10.1016/j.cell.2014.10.050

PMID: 25416956

Résumé

Animals

Databases, Protein

Genome-Wide Association Study

Humans

Mice

Neoplasms - metabolism

Protein Interaction Maps

Proteome - metabolism

Just as reference genome sequences revolutionized human genetics, reference maps of interactome networks will be critical to fully understand genotype-phenotype relationships. Here, we describe a systematic map of ?14,000 high-quality human binary protein-protein interactions. At equal quality, this map is ?30% larger than what is available from small-scale studies published in the literature in the last few decades. While currently available information is highly biased and only covers a relatively small portion of the proteome, our systematic map appears strikingly more homogeneous, revealing a "broader" human interactome network than currently appreciated. The map also uncovers significant interconnectivity between known and candidate cancer gene products, providing unbiased evidence for an expanded functional cancer landscape, while demonstrating how high-quality interactome models will help "connect the dots" of the genomic revolution.

Indicateurs

1 Consultations de la notice

See more details

Détails

Titre: A proteome-scale map of the human interactome network
Créateurs - sans rôle: Thomas Rolland
Murat Taşan
Benoit Charloteaux
Samuel J Pevzner
Quan Zhong
Nidhi Sahni
Song Yi
Irma Lemmens - Department of Medical Protein Research, VIB, 9000 Ghent, Belgium
Celia Fontanillo - Cancer Research Center (Centro de Investigación del Cancer), University of Salamanca and Consejo Superior de Investigaciones Científicas, Salamanca 37008, Spain
Roberto Mosca - Joint IRB-BSC Program in Computational Biology, Institute for Research in Biomedicine (IRB Barcelona), Barcelona 08028, Spain
Atanas Kamburov
Susan D Ghiassian
Xinping Yang
Lila Ghamsari
Dawit Balcha
Bridget E Begg
Pascal Braun
Marc Brehme
Martin P Broly
Anne-Ruxandra Carvunis
Dan Convery-Zupan
Roser Corominas - Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Jasmin Coulombe-Huntington
Elizabeth Dann
Matija Dreze
Amélie Dricot
Changyu Fan
Eric Franzosa
Fana Gebreab
Bryan J Gutierrez
Madeleine F Hardy
Mike Jin
Shuli Kang - Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Ruth Kiros
Guan Ning Lin - Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Katja Luck
Andrew MacWilliams
Jörg Menche
Ryan R Murray
Alexandre Palagi
Matthew M Poulin
Xavier Rambout
John Rasla
Patrick Reichert
Viviana Romero
Elien Ruyssinck - Department of Medical Protein Research, VIB, 9000 Ghent, Belgium
Julie M Sahalie
Annemarie Scholz
Akash A Shah
Amitabh Sharma
Yun Shen
Kerstin Spirohn
Stanley Tam
Alexander O Tejeda
Shelly A Wanamaker
Jean-Claude Twizere
Kerwin Vega
Jennifer Walsh
Michael E Cusick
Yu Xia
Albert-László Barabási
Lilia M Iakoucheva - Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Patrick Aloy
Javier De Las Rivas - Cancer Research Center (Centro de Investigación del Cancer), University of Salamanca and Consejo Superior de Investigaciones Científicas, Salamanca 37008, Spain
Jan Tavernier - Department of Medical Protein Research, VIB, 9000 Ghent, Belgium
Michael A Calderwood
David E Hill
Tong Hao
Frederick P Roth
Marc Vidal
Détails de publication: Cell, Vol.159(5), pp.1212-1226
Note de subvention: U01HG001715 / NHGRI NIH HHS U54 CA112962 / NCI NIH HHS R01 HD065288 / NICHD NIH HHS P50HG004233 / NHGRI NIH HHS U01HL108630 / NHLBI NIH HHS R33CA132073 / NCI NIH HHS R01 HG001715 / NHGRI NIH HHS R01MH105524 / NIMH NIH HHS U54CA112962 / NCI NIH HHS R01 MH105524 / NIMH NIH HHS
Identifiants: 99149640109311
Unité académique: Centre de Recherche en Biologie Cellulaire de Montpellier - CRBM
Langue: English
Type de ressource: Journal article