A phase 1 clinical trial of the selective BTK inhibitor ONO/GS-4059 in relapsed and refractory mature B-cell malignancies

H. S. Walter; S. A. Rule; M. J. S. Dyer; L. Karlin; C. Jones; B. Cazin; Philippe Quittet; N. Shah; C. V. Hutchinson; H. Honda; K. Duffy; J. Birkett; V. Jamieson; N. Courtenay-Luck; T. Yoshizawa; J. Sharpe; T. Ohno; S. Abe; A. Nishimura; Guillaume Cartron; F. Morschhauser; C. Fegan; Gilles Salles

doi:10.1182/blood-2015-08-664086

$A phase 1 clinical trial of the selective BTK inhibitor ONO/GS-4059 in relapsed and refractory mature B-cell malignancies$

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A phase 1 clinical trial of the selective BTK inhibitor ONO/GS-4059 in relapsed and refractory mature B-cell malignancies

H. S. Walter, S. A. Rule, M. J. S. Dyer, L. Karlin, C. Jones, B. Cazin, Philippe Quittet, N. Shah, C. V. Hutchinson, H. Honda, …

Blood, Vol.127(4), pp.411-419

01/2016

DOI: https://doi.org/10.1182/blood-2015-08-664086

PMCID: PMC4731845

Abstract

toxicity

therapeutic use

80 and over

therapy

Adult

adverse effects

B-Cell

Chronic

B-Lymphocytes

Diffuse

Cohort Studies

blood

Diarrhea

drug effects

drug therapy

Female

Imidazoles

France

Hematoma

Hematology

Humans

Large B-Cell

Local Access Right

Leukemia

London

Lymphocytic

Male

Mantle-Cell

pathology

Neoplasm Recurrence

Lymphoma

Medicine

Patients

Pyrimidines

Protein Kinase Inhibitors

Protein-Tyrosine Kinases

antagonists & inhibitors

Aged

Middle Aged

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Title: A phase 1 clinical trial of the selective BTK inhibitor ONO/GS-4059 in relapsed and refractory mature B-cell malignancies
Creators - without role: H. S. Walter - University of Leicester
S. A. Rule - University Hospitals Plymouth NHS Trust
M. J. S. Dyer - University of Leicester
L. Karlin - Hôpital Lyon Sud
C. Jones - Cardiff University
B. Cazin - Université de Lille
Philippe Quittet - Université de Montpellier, Laboratory of Pathogens and Host Immunity - LPHI
N. Shah - University Hospitals Plymouth NHS Trust
C. V. Hutchinson - Plymouth Hospital
H. Honda - Ono Pharmaceutical
K. Duffy - Ono Pharmaceutical
J. Birkett - Ono Pharmaceutical
V. Jamieson - Ono Pharmaceutical
N. Courtenay-Luck - Ono Pharmaceutical
T. Yoshizawa - Ono Pharmaceutical
J. Sharpe - Ono Pharmaceutical
T. Ohno - Ono Pharmaceutical
S. Abe - Ono Pharmaceutical
A. Nishimura - Ono Pharmaceutical
Guillaume Cartron - Université de Montpellier, Laboratory of Pathogens and Host Immunity - LPHI
F. Morschhauser - Centre Hospitalier Universitaire de Lille
C. Fegan - Cardiff University
Gilles Salles - Hôpital Lyon Sud
Publication Details: Blood, Vol.127(4), pp.411-419
Identifiers: 9942442709311
Academic Unit: Laboratory of Pathogens and Host Immunity - LPHI
Language: English
Resource Type: Journal article
Local Fields: hal-01796198