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A negative feedback loop mediated by the Bcl6-cullin 3 complex limits Tfh cell differentiation
Article de revue   Avec comité de lecture

A negative feedback loop mediated by the Bcl6-cullin 3 complex limits Tfh cell differentiation

Rebecca Mathew, Ai-ping Mao, Andrew H Chiang, Clara Bertozzi-Villa, Jeffrey J Bunker, Seth T Scanlon, Benjamin D McDonald, Michael G Constantinides, Kristin Hollister, Jeffrey D Singer, …
The Journal of experimental medicine, Vol.211(6), pp.1137-1151
02/06/2014
PMID: 24863065

Résumé

Animals Basic-Leucine Zipper Transcription Factors - genetics Basic-Leucine Zipper Transcription Factors - immunology Basic-Leucine Zipper Transcription Factors - metabolism Blotting, Western CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Cell Differentiation - genetics Cell Differentiation - immunology Cullin Proteins - genetics Cullin Proteins - immunology Cullin Proteins - metabolism Feedback, Physiological HeLa Cells Humans Mice Mice, Inbred C57BL Mice, Inbred Strains Mice, Knockout Mice, Transgenic Oligonucleotide Array Sequence Analysis Promoter Regions, Genetic - genetics Promoter Regions, Genetic - immunology Protein Binding - immunology Proto-Oncogene Proteins c-bcl-6 - genetics Proto-Oncogene Proteins c-bcl-6 - immunology Proto-Oncogene Proteins c-bcl-6 - metabolism Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - immunology Receptors, Antigen, T-Cell - metabolism Reverse Transcriptase Polymerase Chain Reaction Spleen - cytology Spleen - immunology Spleen - metabolism T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - metabolism Thymocytes - immunology Thymocytes - metabolism Transcriptome - immunology

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