A meta-analysis of genome-wide association studies identifies multiple longevity genes

Joris Deelen; Daniel Evans; Dan E. Arking; Niccolò Tesi; Marianne Nygaard; Xiaomin Liu; Mary Wojczynski; Mary Biggs; Ashley van Der Spek; Gil Atzmon; Erin Ware; Chloé Sarnowski; Albert Smith; Ilkka Seppälä; Heather J. Cordell; Janina Dose; Najaf Amin; Alice Arnold; Kristin Ayers; Nir Barzilai; Elizabeth Becker; Marian Beekman; Hélène Blanché; Kaare Christensen; Lene Christiansen; Joanna Collerton; Sarah Cubaynes; Steven Cummings; Karen Davies; Birgit Debrabant; Jean-François Deleuze; Rachel Duncan; Jessica Faul; Claudio Franceschi; Pilar Galan; Vilmundur Gudnason; Tamara B. Harris; Martijn Huisman; Mikko Hurme; Carol Jagger; Iris Jansen; Marja Jylhä; Mika Kähönen; David Karasik; Sharon Kardia; Andrew Kingston; Thomas Kirkwood; Lenore Launer; Terho Lehtimäki; Wolfgang Lieb; Leo-Pekka Lyytikäinen; Carmen Martin-Ruiz; Junxia Min; Almut Nebel; Anne Newman; Chao Nie; Ellen Nohr; Eric Orwoll; Thomas Perls; Michael Province; Bruce Psaty; Olli Raitakari; Marcel Reinders; Jm Robine; Jerome Rotter; Paola Sebastiani; Jennifer Smith; Thorkild I. A. Sørensen; Kent D Taylor; André G. Uitterlinden; Wiesje van Der Flier; Sven van Der Lee; Cornelia M. van Duijn; Diana van Heemst; James Vaupel; David Weir; Kenny Ye; Yi Zeng; Wanlin Zheng; Henne Holstege; Douglas Kiel; Kathryn Lunetta; P. Eline Slagboom; Joanne Murabito

doi:10.1038/s41467-019-11558-2

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A meta-analysis of genome-wide association studies identifies multiple longevity genes

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A meta-analysis of genome-wide association studies identifies multiple longevity genes

Joris Deelen, Daniel Evans, Dan E. Arking, Niccolò Tesi, Marianne Nygaard, Xiaomin Liu, Mary Wojczynski, Mary Biggs, Ashley van Der Spek, Gil Atzmon, …

Nature Communications, Vol.10(1)

12/2019

DOI: https://doi.org/10.1038/s41467-019-11558-2

PMID: 31413261

Résumé

A meta-analysis of genome-wide association studies identifies multiple longevity genes Joris Deelen et al. # Human longevity is heritable, but genome-wide association (GWA) studies have had limited success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity phenotype definition including 11,262/3484 cases surviving at or beyond the age corresponding to the 90th/99th survival percentile, respectively, and 25,483 controls whose age at death or at last contact was at or below the age corresponding to the 60th survival percentile. Consistent with previous reports, rs429358 (apolipoprotein E (ApoE) ε4) is associated with lower odds of surviving to the 90th and 99th percentile age, while rs7412 (ApoE ε2) shows the opposite. Moreover, rs7676745, located near GPR78, associates with lower odds of surviving to the 90th percentile age. Gene-level association analysis reveals a role for tissue-specific expression of multiple genes in longevity. Finally, genetic correlation of the longevity GWA results with that of several disease-related phenotypes points to a shared genetic architecture between health and longevity.

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Titre: A meta-analysis of genome-wide association studies identifies multiple longevity genes
Créateurs - sans rôle: Joris Deelen - Max Planck Institute for Biology of Ageing
Daniel Evans - California Pacific Medical Center
Dan E. Arking - Johns Hopkins Medicine
Niccolò Tesi - Vrije Universiteit Amsterdam
Marianne Nygaard - University of Southern Denmark
Xiaomin Liu - China National GeneBank
Mary Wojczynski - Statistical Research
Mary Biggs - Cancer Research And Biostatistics
Ashley van Der Spek - Rotterdam University of Applied Sciences
Gil Atzmon - The Bronx Defenders
Erin Ware - Inslaw
Chloé Sarnowski - Boston University
Albert Smith - University of Michigan
Ilkka Seppälä - 358
Heather J. Cordell - Centre for Life
Janina Dose - Institute of Molecular Biology
Najaf Amin - Sema4
Alice Arnold - University of Washington
Kristin Ayers - Sema4
Nir Barzilai - The Bronx Defenders
Elizabeth Becker - Boston University
Marian Beekman - Leiden University Medical Center
Hélène Blanché - Fondation Jean Dausset-CEPH
Kaare Christensen - University of Southern Denmark
Lene Christiansen - University of Southern Denmark
Joanna Collerton - Royal Victoria Infirmary
Sarah Cubaynes - Université de Montpellier, Mécanismes Moléculaires dans les Démences Neurodégénératives - MMDN
Steven Cummings - California Pacific Medical Center
Karen Davies - Newcastle University
Birgit Debrabant - Odense University Hospital
Jean-François Deleuze - Fondation Jean Dausset-CEPH
Rachel Duncan - Newcastle University
Jessica Faul - Institute for Social Research
Claudio Franceschi - Istituti di Ricovero e Cura a Carattere Scientifico
Pilar Galan - Centre de Recherche Épidémiologie et Statistique
Vilmundur Gudnason - Icelandic Heart Association
Tamara B. Harris - National Institute on Aging
Martijn Huisman - Public Health Service of Amsterdam
Mikko Hurme - Tampere University of Applied Sciences
Carol Jagger - Newcastle Hospitals - Campus for Ageing and Vitality
Iris Jansen - Amsterdam University Medical Centers
Marja Jylhä - Tampere University
Mika Kähönen - Tampere University
David Karasik - Tampere University Hospital
Sharon Kardia - School of Public Health
Andrew Kingston - Royal Victoria Infirmary
Thomas Kirkwood - Newcastle University
Lenore Launer - National Institute on Aging
Terho Lehtimäki - Tampere University
Wolfgang Lieb - Christian-Albrechts-Universität zu Kiel
Leo-Pekka Lyytikäinen - Faculty
Carmen Martin-Ruiz - Newcastle University
Junxia Min - Zhejiang University
Almut Nebel - Institute of Molecular Biology
Anne Newman - University of Pittsburgh
Chao Nie - BGI Group
Ellen Nohr - University of Southern Denmark
Eric Orwoll - Oregon Health & Science University
Thomas Perls - Boston University
Michael Province - Washington University in St. Louis
Bruce Psaty - University of Washington
Olli Raitakari - University of Turku
Marcel Reinders - Delft University of Technology
Jm Robine - Université de Montpellier, Mécanismes Moléculaires dans les Démences Neurodégénératives - MMDN
Jerome Rotter - The Lundquist Institute
Paola Sebastiani - Boston University
Jennifer Smith - Institute for Social Research
Thorkild I. A. Sørensen - MRC Integrative Epidemiology Unit
Kent D Taylor - The Lundquist Institute
André G. Uitterlinden - Maasstad Ziekenhuis
Wiesje van Der Flier - Vrije Universiteit Amsterdam
Sven van Der Lee - Vrije Universiteit Amsterdam
Cornelia M. van Duijn - University of Oxford
Diana van Heemst - Leiden University Medical Center
James Vaupel - Max Planck Institute for Demographic Research
David Weir - University of Michigan
Kenny Ye - Albert Einstein College of Medicine
Yi Zeng - Duke University
Wanlin Zheng - California Pacific Medical Center
Henne Holstege - Amsterdam UMC Location University of Amsterdam
Douglas Kiel - Harvard University
Kathryn Lunetta - Boston University
P. Eline Slagboom - Leiden University Medical Center
Joanne Murabito - Boston University
Détails de publication: Nature Communications, Vol.10(1)
Identifiants: 99160713009311
Unité académique: Mécanismes Moléculaires dans les Démences Neurodégénératives - MMDN
Langue: English
Type de ressource: Journal article
Champs locaux: hal-02530209