A map of the interactome network of the metazoan C-elegans

S. M. Li; C. M. Armstrong; N. Bertin; H. Ge; S. Milstein; M. Boxem; P. O. Vidalain; J. D. J. Han; A. Chesneau; T. Hao; D. S. Goldberg; N. Li; M. Martinez; J. F. Rual; P. Lamesch; L. Xu; M. Tewari; S. L. Wong; L. V. Zhang; G. F. Berriz; L. Jacotot; P. Vaglio; J. Reboul; T. Hirozane-Kishikawa; Q. R. Li; H. W. Gabel; A. Elewa; B. Baumgartner; D. J. Rose; H. Y. Yu; S. Bosak; R. Sequerra; A. Fraser; S. E. Mango; W. M. Saxton; S. Strome; S. van Den Heuvel; F. Piano; J. Vandenhaute; C. Sardet; M. Gerstein; L. Doucette-Stamm; K. C. Gunsalus; J. W. Harper; M. E. Cusick; F. P. Roth; D. E. Hill; M. Vidal

doi:10.1126/science.1091403

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A map of the interactome network of the metazoan C-elegans

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A map of the interactome network of the metazoan C-elegans

S. M. Li, C. M. Armstrong, N. Bertin, H. Ge, S. Milstein, M. Boxem, P. O. Vidalain, J. D. J. Han, A. Chesneau, T. Hao, …

Science, Vol.303(5657), pp.540--543

2004

DOI: https://doi.org/10.1126/science.1091403

PMCID: PMC1698949

Résumé

protein-protein interactions caenorhabditis-elegans saccharomyces-cerevisiae gene-expression eye development genome identification information drosophila complexes

To initiate studies on how protein-protein interaction (or "interactome") networks relate to multicellular functions, we have mapped a large fraction of the Caenorhabditis elegans interactome network. Starting with a subset of metazoan-specific proteins, more than 4000 interactions were identified from high-throughput, yeast two-hybrid (HT=Y2H) screens. Independent coaffinity purification assays experimentally validated the overall quality of this Y2H data set. Together with already described Y2H interactions and interologs predicted in silico, the current version of the Worm Interactome (WI5) map contains similar to5500 interactions. Topological and biological features of this interactome network, as well as its integration with phenome and transcriptome data sets, lead to numerous biological hypotheses.

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Titre: A map of the interactome network of the metazoan C-elegans
Créateurs - sans rôle: S. M. Li - Dana-Farber Cancer Institute
C. M. Armstrong - Dana-Farber Cancer Institute
N. Bertin - Harvard University
H. Ge - Harvard University
S. Milstein - Harvard University
M. Boxem - Dana-Farber Cancer Institute
P. O. Vidalain - Dana-Farber Cancer Institute
J. D. J. Han - Dana-Farber Cancer Institute
A. Chesneau - Dana-Farber Cancer Institute
T. Hao - Harvard University
D. S. Goldberg - Harvard University
N. Li - Dana-Farber Cancer Institute
M. Martinez - Harvard University
J. F. Rual - Harvard University
P. Lamesch - Harvard University
L. Xu - Harvard University
M. Tewari - Harvard University
S. L. Wong - Dana-Farber Cancer Institute
L. V. Zhang - Harvard University
G. F. Berriz - Dana-Farber Cancer Institute
L. Jacotot - Dana-Farber Cancer Institute
P. Vaglio - Dana-Farber Cancer Institute
J. Reboul - Dana-Farber Cancer Institute
T. Hirozane-Kishikawa - Harvard University
Q. R. Li - Dana-Farber Cancer Institute
H. W. Gabel - Dana-Farber Cancer Institute
A. Elewa - Dana-Farber Cancer Institute
B. Baumgartner - Dana-Farber Cancer Institute
D. J. Rose - Harvard University
H. Y. Yu - Dana-Farber Cancer Institute
S. Bosak - Dana-Farber Cancer Institute
R. Sequerra - Harvard University
A. Fraser - Dana-Farber Cancer Institute
S. E. Mango - Dana-Farber Cancer Institute
W. M. Saxton - Dana-Farber Cancer Institute
S. Strome - Harvard University
S. van Den Heuvel
F. Piano - Dana-Farber Cancer Institute
J. Vandenhaute - Harvard University
C. Sardet - Université de Montpellier, Institut de Génétique Moléculaire de Montpellier - IGMM
M. Gerstein - Dana-Farber Cancer Institute
L. Doucette-Stamm - Harvard University
K. C. Gunsalus - Harvard University
J. W. Harper - Dana-Farber Cancer Institute
M. E. Cusick - Dana-Farber Cancer Institute
F. P. Roth - Dana-Farber Cancer Institute
D. E. Hill - Harvard University
M. Vidal - Harvard University
Détails de publication: Science, Vol.303(5657), pp.540--543
Identifiants: 99160984009311
Unité académique: Institut de Génétique Moléculaire de Montpellier - IGMM
Langue: English
Type de ressource: Journal article
Champs locaux: hal-02262415