Résumé
ABSTRACT In yeast, the SNF/SWI complex is involved in transcriptional activation of several inducible promoters, possiblyby causing a local modification of the chromatin structure. Recently, two human homologues of the SNF2/SWI2 proteinhave been isolated, hbrm and BAG-1. In addition, a complex containing one of the SNF2/SWI2 homologues and having anIn vitro activity similar to the yeast complex has been partially purified from HeLa cells. Here we describe the characterization of a cDNA encoding a human nuclear protein containing a large domain of homology with SNF5, another member of the yeast SNF/SW1 complex. This protein can be co-immunoprecipitated with hbrm and the interaction between the two proteins is dependent on the region conserved between the human and the yeast SNF5. These findings suggest that the cDNA we have cloned encodes one of the members of the human SNF/SWI complex.