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A “Multi‐Heavy‐Atom” Approach Toward Biphotonic Photosensitizers With Improved Singlet Oxygen Generation Properties
Journal article   Peer reviewed

A “Multi‐Heavy‐Atom” Approach Toward Biphotonic Photosensitizers With Improved Singlet Oxygen Generation Properties

Margaux Galland, Tangui Le Bahers, Akos Banyasz, Noëlle Lascoux, Alain Duperray, Alexei Grichine, Raphaël Tripier, Yannick Guyot, Marie Maynadier, Christophe Nguyen, …
Chemistry - A European Journal, Vol.25(38), pp.9026-9034
11/04/2019
PMID: 30972809

Abstract

TACN Gd Complex Photodynamic Therapy O2 Intersystem crossing Two-photon microscopy Lanthanide
The TACN based gadolinium complex exhibits high two-photon absorption cross-section combined with near-unity 1O2 generation. The very large inter system crossing efficiency induced by the combination of bromine atom and heavy rare-earth element was corroborated with theoretical calculations. The 1O2 generation properties of micellar suspensions under two-photon activation lead to tumour cells death introducing the potential of such structures for theranostic applications
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