Résumé
A simple and effective preparation of 2-hydrogeno-5H-1,2-oxaphosphole 2-oxides 9a–b has been developed involving direct cyclization of H-phosphinic allenes. H-1,2-Oxaphospholenes 9a–b showed to be excellent building blocks for diversity oriented small chemical libraries. Then, reactivity of the cyclic H-phosphinates 9a–b was investigated through Pd(0) catalyzed arylation, Pudovik and three-component Kabachnik–Fields reactions. 5H-1,2-Oxaphospholes are excellent heterocyclic platforms offering different opportunities to modulate the substituent directly bounded to the phosphorus atom.
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