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1,3-Dihydrobenzo[ c ]furan nucleoside analogues: additional studies of the thymine derivative
Journal article   Peer reviewed

1,3-Dihydrobenzo[ c ]furan nucleoside analogues: additional studies of the thymine derivative

David Egron, Christian Perigaud, Gilles Gosselin, Anne-Marie Aubertin, Abdesslem Faraj, Majid Sélouane, Denis Postel and Christophe Len
Bioorganic and Medicinal Chemistry Letters, Vol.13(24), pp.4473-4475
12/2003
PMID: 14643349

Abstract

The detailed study of the 1,3-dihydrobenzo[c]furan derivative of thymine is reported. The lack of anti-HIV activity of this compound in cell culture experiments is shown to be related to the inability of the corresponding 5'-triphosphate derivative to interact efficiently with the reverse transcriptase.
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