Résumé
The title compound 1,2-di-
O-acetyl-5-
O-benzoyl-3-deoxy-
l-
erythro-pentofuranose (
5), a useful precursor for the stereospecific synthesis of β-
l-nucleoside analogues as potential antiviral agents, has been synthesised by a multi-step reaction sequence from
l-xylose with a 38% overall yield. The preparation involved conversion of
l-xylose to 1,2-
O-isopropylidene-α-
l-xylofuranose which, upon selective 5-O-benzoylation and subsequent radical deoxygenation, provided the protected 3-deoxy sugar derivative. Finally, cleavage of the acetonide group gave the resulting 5-
O-benzoyl-3-deoxy-
l-
erythro-pentose which was acetylated to afford crystalline α,β-
5.