-Isotopic labeling: a suitable tool to study the reactivity of bis lactams

Thibault Coursindel; D. Farran; Jean Martinez; Georges Dewynter

doi:10.1016/j.tetlet.2007.11.159

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-Isotopic labeling: a suitable tool to study the reactivity of bis lactams

Journal article

Peer reviewed

-Isotopic labeling: a suitable tool to study the reactivity of bis lactams

Thibault Coursindel, D. Farran, Jean Martinez and Georges Dewynter

Tetrahedron Letters, Vol.49(5), pp.906-909

2008

DOI: https://doi.org/10.1016/j.tetlet.2007.11.159

Abstract

Diketopiperazine

stereoselective

[n-15]-isotopic labeling

Lactam activation

Stereoselective synthesis

TRAL

The unexpected reactivity of 2,5-diketopiperazines under basic conditions, thanks to N-Boc activation, allows access to valuable pharmacological scaffolds, such as original statine derivatives. Toward this transannular rearrangement of activated lactams (TRAL), we report here the study of his lactam reactivity using -isotopic labeling. (C) 2007 Elsevier Ltd. All rights reserved.

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Title: -Isotopic labeling: a suitable tool to study the reactivity of bis lactams
Creators - without role: Thibault Coursindel - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
D. Farran - Institut des Biomolécules Max Mousseron
Jean Martinez - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Georges Dewynter - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Publication Details: Tetrahedron Letters, Vol.49(5), pp.906-909
Identifiers: 9946434009311
Academic Unit: Institut des Biomolécules Max Mousseron - IBMM
Language: English
Resource Type: Journal article
Local Fields: hal-00430605