Résumé
The simultaneous addition to a suspension of HNa in THF at 50°C of β ketophosphonates,
5
or
6
(obtained by acylation of cupromethyl phosphonate
2
) in the Horner-Wadsworth-Emmons reactions and saturated aldehydes provides good yields of α,β-unsaturated ketones. This has been applied successfully in the synthesis of keto- 12 leukotriene LTB
3
12a
.
The simultaneous addition to a suspension of HNa (THF, 50°C) of β-keto phosphonates In the Horner-Wadsworth-Emmons reactions has been applied successfully In the synthesis of keto-12 leukotriene B3.