Résumé
We conducted a retrospective observational study to determine the diagnostic capabilities of 18-FDG PET in the cancer screening in heart transplant patients. We analyzed 303 18-FDG PET scans performed in heart transplant patients followed at Montpellier University Hospital. Of these, 245 were true negatives, 26 true positives, 26 false positives and 6 false negatives. Sensitivity was calculated at 81%, specificity at 90%, positive predictive value at 50% and negative predictive value at 97%. Multivariate analyses showed an association between the risk of false positives, a graft-PET delay ≥6 years and a CRP ≥10 mg/L. 18-FDG PET performed very well in the follow-up of heart transplant patients for neoplasia screening, with better specificity than sensitivity. However, the study showed that almost FP can be predicted by considering only the graft-PET delay and CRP.