Résumé
Parkinson's disease is a chronic neurodegenerative disorder of the central nervous system. It leads to the degeneration of dopaminergic neurons, but also of neurons of the cholinergic system. Thus, scales have been developed in order to quantify the anticholinergic load of certain drugs and to allow the reduction of anticholinergic side effects. This is a prospective, observational, multicenter analysis over a 12-month period. The study was conducted in two geronto-psychiatric centers, including 65 parkinsonian patients hospitalized for psychiatric disorders. In our study, we used the Anticholinergic Impregnation Coefficient (AIC) scale. The aim was to follow the evolution of the anticholinergic load (AC) at the entry and at the exit of the hospitalization, using the medication reconciliation (MC). 65 anticholinergic scores (ACS) at entry and 57 ACS at exit were calculated. We were able to demonstrate an overall decrease in ACS due to the CM. Thus, prescriptions of atypical neuroleptics are in the majority at discharge. The analysis carried out highlighted the changes in drug treatments carried out in the two geronto-psychiatry services.These changes lead to a variation in the anticholinergic score (ACS). It allows the reduction of certain anticholinergic drugs but not necessarily the reduction of the global AC of a prescription because certain drugs do not have an ACS.