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Étude « TRODUMCRA » : estimation de la prévalence de l'infection du VIH, de l'hépatite C et de l’hépatite B chez les retenus du Centre de rétention administrative (CRA) de Nîmes
Mémoire de Master / Thèse d'exercice   Open Access

Étude « TRODUMCRA » : estimation de la prévalence de l'infection du VIH, de l'hépatite C et de l’hépatite B chez les retenus du Centre de rétention administrative (CRA) de Nîmes

Sandrine Mancy
Masters , Université de Montpellier
29/02/2024

Résumé

Human immunodeficiency virus Hepatitis C virus Migrants Administrative detention center Virus de l’hépatite C Virus de l’hépatite B Migrants Centre de rétention administrative Test rapide d’orientation diagnostique VIH (Virus de l’immunodéficience humaine) Rapid Diagnostic Tests Hepatitis b virus
In France, migrants constitute a significant proportion of people diagnosed with HIV, hepatitis C and B. This study estimated the prevalence of these three viruses among detainees at a French administrative detention center (CRA), through systematic Rapid Diagnostic Test (RDT) screening. Methods: this prospective, single-centre, cross-sectional, pilot study included detainees at the Nîmes CRA from February to December 2022. The primary endpoint was HIV, hepatitis C and hepatitis B prevalence determined by RDT. Secondary outcomes were: co-infections; study acceptability, reasons for non-inclusion and causes of non contributory samples; and concordance between serological tests and RDT. Results: among the 350 people agreeing to participate of 726 eligible, five refused the RDT, leaving 345 analysable participants for a participation rate of 47.52% (345/726). Participants were predominantly male (90%) with an average age of 31 years. The most common country of origin was Algeria (34%). Twenty (6%) had taken drugs intravenously and 240 (70%) had had unprotected sex within a median of 4.92 [1.08; 15] months. Virus prevalence was: 0% HIV; 4.64% [2.42; 6.86] hepatitis C; and 2.32% [1.01; 4.52] hepatitis B. Eleven (73%) of the RDT HCV positive cases were confirmed serologically. RDT detected one false-positive case, as an "anti-HCV Ac" serological test was negative. Of the eight patients with positive HBV RDT, one declined the serology testing, thus 100% (7/7) of the tested RDT positive cases were confirmed by serology. Conclusion: the study highlighted the need to screen detainees for HIV, hepatitis C and B infection and suitability of RDTs.

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