Résumé
One of the causes of sudden cardiac death is long QT syndrome, a channelopathy associated with dysfunction of cardiac repolarization. Long QT syndrome can be congenital or acquired. Iatrogenesis is the main cause of acquired long QT syndrome. Many drugs modify the action of cardiac ion channels, especially the hERG channel. These modifications of cardiac conduction lead to a prolongation of the QT interval which can evolve into torsades de pointes and sudden cardiac death. The objective of this thesis is to review the definition of sudden cardiac death, the electrophysiological mechanisms of the congenital and iatrogenic long QT syndrome using the example of antipsychotics.