Résumé
Whole blood (WB), increasingly used in trauma centers, allows for transfusing an optimal RBC/FFP/platelet ratio and simplifies logistics during hemorrhagic shock (HS). Current studies on WB focus primarily on hemostasis, with little attention to hemodynamic effects. This study aimed to compare the volumes needed to achieve a mean arterial pressure (MAP) of 60 mmHg between WB and isotonic saline (IS) in a controlled hemorrhagic shock model in pigs. Method: this was a randomized controlled study on an anesthetized porcine model of controlled hemorrhagic shock. The primary objective was to demonstrate that a smaller volume of WB was required to restore a MAP of 60 mmHg compared to IS. Secondary objectives were to compare biological, ultrasound, and hemodynamic measurements between the two groups. Results: sixteen piglets were included and randomized. The median volume required to reach a MAP of 60 mmHg was 23 [20; 24] mL.Kg-1 for the IS group and 12 [10; 14] mL.Kg-1 for the WB group (p<0.01). The subaortic velocity-time integral was lower in the WB group than in the IS group at the end of the experiment. Other measurements were not inferior in the WB group compared to the IS group. Conclusion: the WB infusion volume appeared to be lower than that of IS in restoring effective hemodynamics in this controlled porcine hemorrhagic shock model.