Résumé
Dissociative symptoms occur in prevalent psychiatric illnesses, but they are particularly frequent in Dissociative Disorders and Functional Neurological Disorders. Although the physiopathology of these disorders remains largely unknown, it has been related to the impairment of cognitive control abilities. Evidence suggests that psilocybin is likely to enhance cognitive control, but no clinical trial has evaluated the value of psilocybin in Dissociative Disorders and Functional Neurological Disorders. We believe that Functional/dissociative Seizures constitute a good model to study the effect of therapeutic interventions on dissociative phenomena. To investigate the effect of psilocybin on cerebral networks, we propose to target the circuits associated with cognitive control and their interactions with the processing of emotional information by quantifying changes in the activity of the cognitive control network in functional brain MRI during an emotional Go-No Go task.