Abstract
In our work, we present a new technique for the activation of the B-H to B-L bond of closodecaborate. Therefore, we followed the pathway of dicages synthesis starting from monocages. New derivatives [B10H9LL'B10H9]4- resulting from the coupling between two monocages [B10H9L]- and [B10H9L']- were successfully synthesized and characterized by IR, 11B NMR, 1H NMR and mass spectrometry.In addition, a functionalization of the cage with bioactive molecules "sulfonamides" was the focus of our research. We were also able to isolate the products resulting from the coupling between (PPh4) [2-B10H9CO] and sulfonamides. The latter were characterized by IR, 11B NMR, 1H NMR, 13C NMR, 31P NMR and mass spectrometry.Finally, a very new method has been exposed in our work. It is based on the functionalization of [B10H10]2- derivatives based on Grignard reactions. Through the coupling between the (PPh4) [2- B10H9CO] derivative and the Grignard RMgX reagents, we synthesized a series of [2-B10H9COR]2- derivatives which were subsequently characterized by IR, 11B NMR, 1H NMR, 13C NMR, 31P NMR and mass spectrometry.Keywords: closo-decahydrodecaborates, BNCT, dicages, bioactive molecule "sulfonamide", Grignard reagents.