Abstract
Delivery of enantiopure molecules represents a crucial issue for the synthesis of biologically active compounds, particularly for the pharmaceutical and agrochemical industries. While there are several ways for the access to each enantiomer, enantioselective synthesis from chiral catalysts presents key advantages over the other methodologies: reducing production costs and wastes, and for the best catalyzed reactions having high atom economy. All these parameters are critical for further development at industrial scale. Phosphorus ligands aroused early specific interest in asymmetric catalysis. Recently, the emergence of ligands with unprecedented heteroaromatic cores allowed fine tuning and modulation of both electronic properties and structural parameters, making them particularly attractive for organic chemists.This work is devoted to the research and synthesis of new phosphorus objects with potential axial chirality. These researches deal with the synthesis of imidazo[1,2-a] pyridines, a 10 π-electron biheterocylic system. Easy functionalization of this heterocyclic core at dedicated positions constitutes the main goal of this work. A second objective of our work was dedicated to the enantioselective synthesis of bêta-aminoalcohols from chiral phosphine oxides.