Abstract
In the last decade a new cell population involved in innate immunity was identified in mice and then confirmed in humans. These cells dubbed innate lymphoid cells (or ILCs) are characterized by a lymphoid morphology. Since 2013 a nomenclature was proposed accordingto the similarities of the transcription factor expression and cytokines profiles to CD4+ T cells. There are currently 3 groups of ILCs: ILC1, ILC2 and ILC3, which mirror of the Th1, Th2 and Th17/22 CD4+ T cells, respectively.ILCs studies have been performed most in mice, while the study of ILCs in humans mainly address their role during an anti-allergic or pro-inflammatory response. ILCs have a crucial role within various biological and immune functions. They are involved in maintaining the integrity of the epithelium and homeostasis, tissue repair, as well as in the rapid response against pathogens. ILCs are in lymphoid and non-lymphoid tissue located through the organism but mostly in mucosal tissue and surface barrier. They represent one of the first immune cells that pathogens encounter. This multi-functionality suggests a potential role of ILCs during antiviral responses.In this study, I was interested by the implication of ILCs in an adenovirus response. Adenovirus infections are one of the most common infections in all populations leading to the presence of well characterized immunity. We are examining the epithelial cells, dendritic cells, antibodies, ILCs and adenovirus during interaction in the context of primo-infections and vaccination.