Abstract
The aim of the present research is to develop new, rapid and efficient methodologies for the synthesis of five and six membered heterocycles. The use of amino alcohols and/or propargylic alcohols as starting materials is our strategy to obtain new heterocycles. In this work, we focused on developing efficient methodologies of polyfunctionalized oxazolone-5-carboxylates from cis- or trans-N-alkyloxazolidin-2-ones, and pyrimidines bearing stereogenic center at the C2 position, including C-terminal peptide isosters.