Abstract
Isoprostanes are non-enzymatically generated metabolites of polyunsaturated fatty acids (PUFA), and are ubiquitous in vertebrate species. As they are produced by the action of free oxygenated radicals on PUFA, they are considered as excellent oxidative stress biomarkers in the organisms. The synthesis of isoprostanoids is necessary to determine their potential as biomarkers of oxidative stress by LC-MS/MS analysis. The aim of the work reported in this thesis is the development of organocatalytic synthesis pathways of new metabolites, possessing all-cis and cis-trans-trans (prostaglandins stereochemistries and derived from docosahexaenoic and eicosapentaenoic acids.