Résumé
In this study, we aimed to show the feasibility of the preparation of biomimetic hybrid vectors combining liposomes with a Prussian blue coating for theranostic application. The liposomes would allow us to encapsulate drugs, while the Prussian blue outer layer would provide photothermal and contrasting features to the vector. The Prussian blue deposition has first been optimized on a simple amino-gold flat surface, on which we deposited Prussian blue Analog preformed particles. Then, a new method of Prussian blue preparation has been developed, by simultaneous addition of Prussian blue precursors, to grow nanostructures directly on the flat surface model. This model was then improved by depositing a supported lipid bilayer on top of it. It made possible the growth of Prussian blue structures on a flat lipid bilayer, still by our rapid method of simultaneous addition. Then, the influence of the lipid bilayer composition was studied, as well as the interaction time between the Prussian blue precursors and the lipids. Finally, it has been showed that the deposition of Prussian blue nanostructures could also be performed on a spherical model of supported lipid bilayer, paving the way to the coating of liposomes encapsulating drugs