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1-(Arylsulfonyl-isoindol-2-yl)piperazines as 5-HT6R antagonists: mechanochemical synthesis, in vitro pharmacological properties and glioprotective activity - research data
Jeu de données

1-(Arylsulfonyl-isoindol-2-yl)piperazines as 5-HT6R antagonists: mechanochemical synthesis, in vitro pharmacological properties and glioprotective activity - research data

Vittorio Canale, Wojciech Trybała, Severine Chaumont-Dubel, Paulina Koczurkiewicz-Adamczyk, Grzegorz Satała, Ophélie Bento, Klaudia Blicharz-Futera, Xavier Bantreil, Elżbieta Pękala, Andrzej J. Bojarski, …
OMEGA-PSIR
29/08/2024
DOI: https://doi.org/10.60731/ujcm.290824

Résumé

Characterization of all intermediates; UPLC-MS, 1H-NMR, and 13C-NMR of all intermediates and final compounds; Table S1–SI: Optimization of milling conditions for sulfonylation of isoindolines 1a–d; Table S2–SI: Optimization of milling conditions for SNAr of intermediates 2a–l; Figure S1–SI: The effect of compound 3g on cellular viability.

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