Résumé
Hollow Periodic Mesoporous Organosilica Nanoparticles (HPMO-NPs) with a controlled core cavity and a Periodic Mesoporous Organosilica (PMO) shell have been synthesized using a dual templating approach. A dense silica hard template is firstly prepared following classical Stöber sol-gel protocol. The hybrid silica shell is then deposited through a one-pot strategy by the co-condensation of the organosilane precursor with surfactant. HPMO-NPs are then obtained after the final etching steps of the hard and soft templates. In this work, we demonstrate that this strategy can be applied to synthesize:a/ HPMO-NPs with controlled diameter sizes ranging from 600 nm to 40 nm, b/ HPMO-NPs with various shell composition by adjusting the nature of the organosilane precursor, c/ Yolk shell structures with a functional central nanoparticle. We will detail the structural properties of the HPMO-NPs using a multi-scale experimental study at the various stages of synthesis, highlighting the role of mesoporosity and the structural organization of the PMO shell on its properties.Finally, in view of medical applications, we will also present endocytosis and biocompatibility preliminary results.