Résumé
Grapevine fanleaf virus (GFLV) and Arabis mosaic virus (ArMV), two nepoviruses highly detrimental to grapes, are specifically transmitted by the ectoparasitic nematodes Xiphinema index and X. diversicaudatum, respectively. This specificity of transmission is determined by the coat protein (2CCP). A 3D model of GFLV was constructed by homology with Tobacco ring spot virus (TRSV) and reverse genetic experiments performed using GFLV-ArMV chimeric 2CCP constructs. This allowed the identification of one external 2CCP domain involved in nematode transmission. Structural studies are ongoing to precisely define the surface residues within GFLV and ArMV 2CCP responsible for this specificity.