Résumé
The present study aims to prepare new composite solid lipid microparticles (CSLM) by hot melt homogenization of a solid lipid, cetyl alcohol, at room temperature, in the presence of hydrophobic silica nanoparticles, Aerosil® R974, to replace the surfactant. Silica nanoparticles are dispersed in water in the same way as the preparation of pickering emulsions, instead of their addition in the melt lipid . We prepared unloaded CSLM or loaded with ibuprofen, a model drug to establish the role of hydrophobic silica nanoparticles on physical characteristics of microparticles, lipid and drug and on release after their incubation in PBS medium.