Qualitative response of interaction networks: application to the validation of biological models

Anne Siegel; Carito Guziolowski; Philippe Veber; Ovidiu Radulescu; Michel Le Borgne

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Qualitative response of interaction networks: application to the validation of biological models

Anne Siegel, Carito Guziolowski, Philippe Veber, Ovidiu Radulescu et Michel Le Borgne

6th International Congress on Industrial and Applied Mathematics. ICIAM 07

2007

Résumé

Bioinformatics

Computer Science

Life Sciences

Quantitative Methods

We advocate the use of qualitative models for the analysis of shift equilibria in large biological systems. We present a mathematical method, allowing qualitative predictions to be made of the behaviour of a biological system. These predictions are not dependent on specific values of the kinetic constants. We show how these methods can be used to improve understanding of a complex regulatory system.

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Détails

Titre: Qualitative response of interaction networks: application to the validation of biological models
Créateurs - sans rôle: Anne Siegel - Biological systems and models, bioinformatics and sequences
Carito Guziolowski - Biological systems and models, bioinformatics and sequences
Philippe Veber - Biological systems and models, bioinformatics and sequences
Ovidiu Radulescu - Biological systems and models, bioinformatics and sequences
Michel Le Borgne - Biological systems and models, bioinformatics and sequences
Détails de publication: 6th International Congress on Industrial and Applied Mathematics. ICIAM 07
Colloque: 6th International Congress on Industrial and Applied Mathematics. ICIAM 07
Identifiants: 99147738909311
Unité académique: Laboratory of Pathogens and Host Immunity - LPHI
Langue: English
Type de ressource: Conference proceeding