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P2.06.43 Estimating Tumour Microenvironment Cellular States From Bulk RNAseq Produces Biomarkers of Clinical Outcome Across Stages
Acte de colloque

P2.06.43 Estimating Tumour Microenvironment Cellular States From Bulk RNAseq Produces Biomarkers of Clinical Outcome Across Stages

M. Hurtado, E. Gobbini, Laurent Greillier, L. Khajavi, A. Essabbar, M. N Kammer, A. Pradines, A. Kruczynski, S. Tabourier-Gouin, E. Tarenchon-Clermont, …
Journal of Thoracic Oncology, Vol.20(10), p.S308-S309
2025 IASLC World Conference on Lung Cancer (Barcelone, Spain, 06/09/2025–09/09/2025)
10/2025
DOI: https://doi.org/10.1016/j.jtho.2025.09.577

Résumé

cell-type deconvolution tumor-microenvironment immunotherapy Meeting abstract
Lung cancer is a complex and heterogeneous disease for which better predictive biomarkers of response are still lacking to guide personalized therapies. A better understanding of the tumor microenvironment (TME) is needed to improve patient outcomes. Here, we propose a novel computational approach that leverages bulk RNA-seq to infer clinically relevant patient-specific cell groups and states, which are normally detectable only with more costly and complex single-cell assays.[...]

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