Résumé
Venomous animals are thought to inject the same combination of toxins for both predation and defence, presumably exploiting conserved target pharmacology across prey and predators: one venom fits all. Remarkably, some species of cone snails were shown to inject different venom compositions for predation and defense. The controlled and selective injection of different conotoxin cocktails suggest that the evolution of cone snail venom is not only under the direct influence of one but at least two, potentially equally important, driving forces: predation and defense. Therefore, it provides a unique opportunity to study venomeecology relationships in unprecedented details, on the condition that both predatory and defensive venoms can be collected and analyzed separately. Some of these venom variations have been characterized, often using a combination of mass spectrometry and transcriptomic methods. Here, I will present the current knowledge on such specific predatory and defensive venoms gathered from sixteen different cone snail species that belong to eight subgenera.