Information processing circuits in cell-free systems: beyond gene expression regulation

Manish Kushwaha; Amir Pandi; Mathilde Koch; Paul Soudier; Angelo Cardoso Batista; Antoine Lévrier; Peter L Voyvodic; Ana Zúñiga; Thomas Duigou; Kenza Bazi-Kabbaj; Julie A. Vendrell; Tatjana Achmedov; Tristan Reif-Trauttmansdorff; Angelique Devisch; Martin Cohen-Gonsaud; Jérôme Solassol; Chase L Beisel; Jerome Bonnet; Jean-Loup Faulon

Information processing circuits in cell-free systems: beyond gene expression regulation

Acte de colloque

Open Access

Information processing circuits in cell-free systems: beyond gene expression regulation

Manish Kushwaha, Amir Pandi, Mathilde Koch, Paul Soudier, Angelo Cardoso Batista, Antoine Lévrier, Peter L Voyvodic, Ana Zúñiga, Thomas Duigou, Kenza Bazi-Kabbaj, …

International Conference on Engineering Synthetic Cells and Organelles (Minneapolis, MN, USA, United States, 22/05/2023–24/05/2023)

Résumé

Cell-free expression systems have emerged as promising tools for implementing information-processing circuits. Most of these circuits employ biosensors directly linked to gene expression regulation, using digital logic encoded on plasmid DNA. Here, we present several new approaches for building biological circuits that process information via metabolic transducers: combining analogue and digital logic in the metabolic perceptron, routing metabolic sensing through a common hub molecule, and screening transducer enzymes using linear DNA templates. The examples introduced here lay the groundwork for more advanced metabolic circuits for rapid and scalable multiplex sensing.

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Titre: Information processing circuits in cell-free systems: beyond gene expression regulation
Créateurs - sans rôle: Manish Kushwaha - Microbiologie de l’alimentation au service de la santé
Amir Pandi - Microbiologie de l’alimentation au service de la santé
Mathilde Koch - Microbiologie de l’alimentation au service de la santé
Paul Soudier - Microbiologie de l’alimentation au service de la santé
Angelo Cardoso Batista - Microbiologie de l’alimentation au service de la santé
Antoine Lévrier - Université de Montpellier, Centre de Biologie Structurale - CBS
Peter L Voyvodic - Université de Montpellier, Centre de Biologie Structurale - CBS
Ana Zúñiga - Université de Montpellier, Centre de Biologie Structurale - CBS
Thomas Duigou - Microbiologie de l’alimentation au service de la santé
Kenza Bazi-Kabbaj - Microbiologie de l’alimentation au service de la santé
Julie A. Vendrell - CHU Montpellier = Montpellier University Hospital
Tatjana Achmedov - Helmholtz-Institut für RNA-basierte Infektionsforschung - Helmholtz Institute for RNA‐based Infection Research [Würzburg, Germany]
Tristan Reif-Trauttmansdorff - Microbiologie de l’alimentation au service de la santé
Angelique Devisch - Université de Montpellier, Centre de Biologie Structurale - CBS
Martin Cohen-Gonsaud - Université de Montpellier, Centre de Biologie Structurale - CBS
Jérôme Solassol - CHU Montpellier = Montpellier University Hospital
Chase L Beisel - Helmholtz-Institut für RNA-basierte Infektionsforschung - Helmholtz Institute for RNA‐based Infection Research [Würzburg, Germany]
Jerome Bonnet - Université de Montpellier, Centre de Biologie Structurale - CBS
Jean-Loup Faulon - Microbiologie de l’alimentation au service de la santé
Colloque: International Conference on Engineering Synthetic Cells and Organelles (Minneapolis, MN, USA, United States, 22/05/2023–24/05/2023)
Identifiants: 99107062109311
Unité académique: Centre de Biologie Structurale - CBS
Langue: English
Type de ressource: Conference proceeding
Champs locaux: hal-04563028