Résumé
Despite the impressive recent achievement in the asymmetric aldol methodology, involvement of prochiral ketones into stereo controlled aldol addition reactions still remains one of the most challenging synthetic targets [1]. In particular, aldol condensations between chiral glycine alpha-anion equivalents and prochiral ketones, performed with a synthetically valuable stereochemical outcome, have not been reported so far [2]. In this communication we would like to report our results in the asymmetric synthesis of beta-hydroxypolyfunctionalized amino acids through the asymmetric aldol reaction of alphaketoesters and di ketones.