Abstract
Glutaredoxins (GRXs) are small oxidoreductases involved in numerous cellular processes, notably through their ability to reduce disulfide bond and cystein-gluthatione bond of target proteins. Often considered as antioxidants helping to minimize oxidative damage to proteins, class III GRXs now appear as major regulators of signaling pathways involved in response to several environmental signals and certain abiotic stresses including nitrate (NO3-) depletion. Morover, these GRXs can interact with transcription factor of the bzip family TGA, regulators of the nitrate root transporters of the NRT2 family involved in nitrate root transport and development of the root system archtecture. Our project aims to understand the role of GRXs in the molecular mechanisms that regulate root development and the absorption/assimilation of NO3-. This will involve studying in particular the function of GRXs in the NO3- signaling pathways in the model plant Arabidopsis thaliana in order to determine if they play a role in nitrate responses.